Homo sapiens Gene: PCDHGB7 | |||||||
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Summary | |||||||
InnateDB Gene | IDBG-408919.3 | ||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
Gene Symbol | PCDHGB7 | ||||||
Gene Name | protocadherin gamma subfamily B, 7 | ||||||
Synonyms | |||||||
Species | Homo sapiens | ||||||
Ensembl Gene | ENSG00000254122 | ||||||
Encoded Proteins |
protocadherin gamma subfamily B, 7
protocadherin gamma subfamily B, 7
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Protein Structure | |||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||
Entrez Gene | |||||||
Summary |
This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||
Type | Protein coding | ||||||
Genomic Location | Chromosome 5:141417645-141512979 | ||||||
Strand | Forward strand | ||||||
Band | q31.3 | ||||||
Transcripts |
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Interactions | |||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||
No orthologs found for this gene | |||||||
Cross-References | |||||||
SwissProt | Q9Y5F8 | ||||||
TrEMBL | Q9BT64 Q9UKW1 | ||||||
UniProt Splice Variant | |||||||
Entrez Gene | 56099 | ||||||
UniGene | |||||||
RefSeq | NM_018927 NM_032101 | ||||||
HUGO | HGNC:8714 | ||||||
OMIM | 606304 | ||||||
CCDS | CCDS47293 CCDS75344 | ||||||
HPRD | 06952 | ||||||
IMGT | |||||||
EMBL | AF119570 AF152336 AF152523 BC004321 BC051788 | ||||||
GenPept | AAD43730 AAD43783 AAF03087 AAH04321 AAH51788 | ||||||
RNA Seq Atlas | 56099 | ||||||