Homo sapiens Gene: PCDHGB7
InnateDB Gene IDBG-408919.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PCDHGB7
Gene Name protocadherin gamma subfamily B, 7
Species Homo sapiens
Ensembl Gene ENSG00000254122
Encoded Proteins
protocadherin gamma subfamily B, 7
protocadherin gamma subfamily B, 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:141417645-141512979
Strand Forward strand
Band q31.3
ENST00000398594 ENSP00000381594
ENST00000612073 ENSP00000479132
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
Biological Process
GO:0007156 homophilic cell adhesion
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
No orthologs found for this gene
SwissProt Q9Y5F8
UniProt Splice Variant
Entrez Gene 56099
RefSeq NM_018927 NM_032101
OMIM 606304
CCDS CCDS47293 CCDS75344
HPRD 06952
EMBL AF119570 AF152336 AF152523 BC004321 BC051788
GenPept AAD43730 AAD43783 AAF03087 AAH04321 AAH51788
RNA Seq Atlas 56099