Homo sapiens Gene: PCDHGC3
Summary
InnateDB Gene IDBG-408922.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PCDHGC3
Gene Name protocadherin gamma subfamily C, 3
Synonyms PC43; PCDH-GAMMA-C3; PCDH2;
Species Homo sapiens
Ensembl Gene ENSG00000240184
Encoded Proteins
protocadherin gamma subfamily C, 3
protocadherin gamma subfamily C, 3
protocadherin gamma subfamily C, 3
protocadherin gamma subfamily C, 3
protocadherin gamma subfamily C, 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:141475947-141512979
Strand Forward strand
Band q31.3
Transcripts
ENST00000308177 ENSP00000312070
ENST00000611950 ENSP00000481219
ENST00000617641 ENSP00000483383
ENST00000616230
ENST00000621008 ENSP00000484352
ENST00000617222 ENSP00000481673
ENST00000622656
ENST00000622836
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
Biological Process
GO:0007156 homophilic cell adhesion
GO:0016339 calcium-dependent cell-cell adhesion
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL Q9BR81 Q9BT64 Q9UKW1
UniProt Splice Variant
Entrez Gene 5098
UniGene
RefSeq NM_032403 NM_002588 NM_032402
HUGO HGNC:8716
OMIM 603627
CCDS CCDS75347 CCDS4261 CCDS75348
HPRD
IMGT
EMBL AF119570 BC004321 BC006439 BC027451 BC063437
GenPept AAF03087 AAH04321 AAH06439 AAH27451 AAH63437
RNA Seq Atlas 5098