Homo sapiens Gene: PCDHGC5
Summary
InnateDB Gene IDBG-408930.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PCDHGC5
Gene Name protocadherin gamma subfamily C, 5
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000240764
Encoded Proteins
protocadherin gamma subfamily C, 5
protocadherin gamma subfamily C, 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:141489121-141512979
Strand Forward strand
Band q31.3
Transcripts
ENST00000252087 ENSP00000252087
ENST00000610789 ENSP00000482569
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
Biological Process
GO:0007156 homophilic cell adhesion
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Cross-References
SwissProt Q9Y5F6
TrEMBL Q9BT64 Q9UKW1
UniProt Splice Variant
Entrez Gene 56097
UniGene
RefSeq NM_018929 NM_032407
HUGO HGNC:8718
OMIM 606306
CCDS CCDS4263 CCDS75350
HPRD 07318
IMGT
EMBL AF119570 AF152339 AF152526 BC004321
GenPept AAD43733 AAD43786 AAF03087 AAH04321
RNA Seq Atlas 56097