Homo sapiens Gene: CEBPA
InnateDB Gene IDBG-409028.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CEBPA
Gene Name CCAAT/enhancer binding protein (C/EBP), alpha
Synonyms C/EBP-alpha; CEBP
Species Homo sapiens
Ensembl Gene ENSG00000245848
Encoded Proteins
CCAAT/enhancer binding protein (C/EBP), alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
[Mus musculus] Cebpa is a member of the CCAAT enhancer binding protein family and is a transcriptional factor regulating genes in innate immunity and inflammation. The activities of CEBP are regulated via methylation of arginine and lysine side chains.
[Mus musculus] Cebpa suppresses granule formation in mast cells and increases Cxcl2 production from mast cells upon bacterial stimulation.
Entrez Gene
Summary The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain promoters and enhancers. It can also form heterodimers with the related proteins CEBP-beta and CEBP-gamma. The encoded protein has been shown to bind to the promoter and modulate the expression of the gene encoding leptin, a protein that plays an important role in body weight homeostasis. Also, the encoded protein can interact with CDK2 and CDK4, thereby inhibiting these kinases and causing growth arrest in cultured cells. [provided by RefSeq, Jul 2008]
This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of this protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. Mutation of this gene is associated with acute myeloid leukemia. The use of alternative in-frame non-AUG (GUG) and AUG start codons results in protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the GUG and the first AUG start codons. [provided by RefSeq, Dec 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:33299934-33302564
Strand Reverse strand
Band q13.11
ENST00000498907 ENSP00000427514
Number of Interactions This gene and/or its encoded proteins are associated with 145 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.
Experimentally validated
Total 145 [view]
Protein-Protein 123 [view]
Protein-DNA 18 [view]
Protein-RNA 0
DNA-DNA 4 [view]
Predicted by orthology
Total 36 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0019904 protein domain specific binding
GO:0032403 protein complex binding
GO:0042803 protein homodimerization activity
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0046982 protein heterodimerization activity
GO:0071837 HMG box domain binding
Biological Process
GO:0000050 urea cycle
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001889 liver development
GO:0001892 embryonic placenta development
GO:0006091 generation of precursor metabolites and energy
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0006953 acute-phase response
GO:0007005 mitochondrion organization
GO:0007584 response to nutrient
GO:0008203 cholesterol metabolic process
GO:0008285 negative regulation of cell proliferation
GO:0016032 viral process
GO:0019221 cytokine-mediated signaling pathway
GO:0030099 myeloid cell differentiation
GO:0030154 cell differentiation
GO:0030225 macrophage differentiation
GO:0030324 lung development
GO:0031100 organ regeneration
GO:0033274 response to vitamin B2
GO:0042127 regulation of cell proliferation
GO:0045087 innate immune response (InnateDB)
GO:0045444 fat cell differentiation
GO:0045600 positive regulation of fat cell differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0045945 positive regulation of transcription from RNA polymerase III promoter
GO:0048469 cell maturation
GO:0048839 inner ear development
GO:0050872 white fat cell differentiation
GO:0050873 brown fat cell differentiation
GO:0051384 response to glucocorticoid
GO:0071285 cellular response to lithium ion
GO:0071407 cellular response to organic cyclic compound
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0016363 nuclear matrix
GO:0035189 Rb-E2F complex
GO:0043234 protein complex
Mus musculus
Gene ID
Gene Order
AndrogenReceptor pathway
EGFR1 pathway
IL4 pathway
Transcriptional regulation of white adipocyte differentiation pathway
Developmental Biology pathway
Acute myeloid leukemia pathway
Pathways in cancer pathway
Validated targets of C-MYC transcriptional repression
C-MYB transcription factor network
E2F transcription factor network
Regulation of Androgen receptor activity
SwissProt P49715
UniProt Splice Variant
Entrez Gene 1050
UniGene Hs.740432
RefSeq NM_001285829 NM_001287424 NM_001287435 NM_004364
OMIM 116897
EMBL BC027902 BC063874 EU048234 U34070 Y11525
GenPept AAC50235 AAH27902 AAH63874 ABS82765 CAA72289
RNA Seq Atlas 1050