|Homo sapiens Gene: CEBPA|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||CCAAT/enhancer binding protein (C/EBP), alpha|
CCAAT/enhancer binding protein (C/EBP), alpha
|Useful resources||Stemformatics EHFPI ImmGen|
|InnateDB Annotation from Orthologs|
[Mus musculus] Cebpa is a member of the CCAAT enhancer binding protein family and is a transcriptional factor regulating genes in innate immunity and inflammation. The activities of CEBP are regulated via methylation of arginine and lysine side chains.
[Mus musculus] Cebpa suppresses granule formation in mast cells and increases Cxcl2 production from mast cells upon bacterial stimulation.
The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain promoters and enhancers. It can also form heterodimers with the related proteins CEBP-beta and CEBP-gamma. The encoded protein has been shown to bind to the promoter and modulate the expression of the gene encoding leptin, a protein that plays an important role in body weight homeostasis. Also, the encoded protein can interact with CDK2 and CDK4, thereby inhibiting these kinases and causing growth arrest in cultured cells. [provided by RefSeq, Jul 2008]
This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of this protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. Mutation of this gene is associated with acute myeloid leukemia. The use of alternative in-frame non-AUG (GUG) and AUG start codons results in protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the GUG and the first AUG start codons. [provided by RefSeq, Dec 2013]
|Genomic Location||Chromosome 19:33299934-33302564|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 145 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.
Transcriptional regulation of white adipocyte differentiation pathway
Developmental Biology pathway
Acute myeloid leukemia pathway
Pathways in cancer pathway
Validated targets of C-MYC transcriptional repression
C-MYB transcription factor network
E2F transcription factor network
Regulation of Androgen receptor activity
|UniProt Splice Variant|
|RefSeq||NM_001285829 NM_001287424 NM_001287435 NM_004364|
|EMBL||BC027902 BC063874 EU048234 U34070 Y11525|
|GenPept||AAC50235 AAH27902 AAH63874 ABS82765 CAA72289|
|RNA Seq Atlas||1050|