Version 5.4
Homo sapiens Gene: MRPS17
Summary
InnateDB Gene IDBG-409046.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MRPS17
Gene Name 28S ribosomal protein S17, mitochondrial; HCG1984214, isoform CRA_a
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000249773
Encoded Proteins
IDBP-375904
28S ribosomal protein S17, mitochondrial
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S17P family. The encoded protein is moderately conserved between human mitochondrial and prokaryotic ribosomal proteins. Pseudogenes corresponding to this gene are found on chromosomes 1p, 3p, 6q, 14p, 18q, and Xq. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:55887277-55955239
Strand Forward strand
Band p11.2
Transcripts
ENST00000426595 ENSP00000390331
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006412 translation
Cellular Component
GO:0005622 intracellular
GO:0005763 mitochondrial small ribosomal subunit
GO:0005840 ribosome
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
hsa03010
Ribosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E9PE17 I3L0E3 Q96Q59
UniProt Splice Variant
Entrez Gene 51373
UniGene
RefSeq
HUGO HGNC:14047
OMIM 611980
CCDS
HPRD
IMGT
EMBL AB049950 AB051352 AC092579 AC092647 AF077035 BC047445 BC054031 CH471140
GenPept AAD27768 AAH47445 AAH54031 BAB41003 BAB54942 EAX07962 EAX07965
RNA Seq Atlas 51373

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca