Version 5.4
Homo sapiens Gene: RGS21
Summary
InnateDB Gene IDBG-409218.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RGS21
Gene Name regulator of G-protein signaling 21
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000253148
Encoded Proteins
IDBP-484936
regulator of G-protein signaling 21
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins are GTPase-activating proteins for Gi (see GNAI1; MIM 139310) and Gq (see GNAQ; MIM 600998) class G-alpha proteins. They accelerate transit through the cycle of GTP binding and hydrolysis and thereby accelerate signaling kinetics and termination.[supplied by OMIM, Nov 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:192316992-192367285
Strand Forward strand
Band q31.2
Transcripts
ENST00000417209 ENSP00000428343
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
Biological Process
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
GO:0038032 termination of G-protein coupled receptor signaling pathway
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_18283
G alpha (q) signalling events pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_19231
G alpha (i) signalling events pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q2M5E4
TrEMBL
UniProt Splice Variant
Entrez Gene 431704
UniGene Hs.558673
RefSeq NM_001039152
HUGO HGNC:26839
OMIM 612407
CCDS CCDS41448
HPRD
IMGT
EMBL AY643711
GenPept AAT64913
RNA Seq Atlas 431704

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca