Homo sapiens Gene: RGS21
Summary
InnateDB Gene IDBG-409218.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RGS21
Gene Name regulator of G-protein signaling 21
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000253148
Encoded Proteins
regulator of G-protein signaling 21
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins are GTPase-activating proteins for Gi (see GNAI1; MIM 139310) and Gq (see GNAQ; MIM 600998) class G-alpha proteins. They accelerate transit through the cycle of GTP binding and hydrolysis and thereby accelerate signaling kinetics and termination.[supplied by OMIM, Nov 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:192316992-192367285
Strand Forward strand
Band q31.2
Transcripts
ENST00000417209 ENSP00000428343
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
Biological Process
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
GO:0038032 termination of G-protein coupled receptor signaling pathway
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
Gastrin-CREB signalling pathway via PKC and MAPK pathway
G alpha (q) signalling events pathway
Signaling by GPCR pathway
Signal Transduction pathway
GPCR downstream signaling pathway
G alpha (i) signalling events pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q2M5E4
TrEMBL
UniProt Splice Variant
Entrez Gene 431704
UniGene Hs.558673
RefSeq NM_001039152
HUGO HGNC:26839
OMIM 612407
CCDS CCDS41448
HPRD
IMGT
EMBL AY643711
GenPept AAT64913
RNA Seq Atlas 431704