InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: FOSL2

Summary

InnateDB Gene

IDBG-41072.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FOSL2

Gene Name

FOS-like antigen 2

Synonyms

FRA2

Species

Homo sapiens

Ensembl Gene

ENSG00000075426

Encoded Proteins

IDBP-41074

FOS-like antigen 2

IDBP-41080

FOS-like antigen 2

IDBP-370632

FOS-like antigen 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. [provided by RefSeq, Jul 2008]
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. [provided by RefSeq, Jul 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:28392448-28417312

Strand

Forward strand

Band

p23.2

Transcripts

ENST00000379619	ENSP00000368939
ENST00000264716	ENSP00000264716
ENST00000436647	ENSP00000396497
ENST00000460736

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	27 [view]
Protein-Protein	20 [view]
Protein-DNA	7 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0007565	female pregnancy
GO:0008219	cell death
GO:0009612	response to mechanical stimulus
GO:0032570	response to progesterone
GO:0032870	cellular response to hormone stimulus
GO:0042493	response to drug
GO:0043278	response to morphine
GO:0048146	positive regulation of fibroblast proliferation
GO:0051412	response to corticosterone
GO:0051591	response to cAMP

Cellular Component

GO:0005634

nucleus

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000029135

View Gene Order

ENSBTAG00000023929

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa04380

Osteoclast differentiation pathway

INOH

INOH website

CD4 T cell receptor signaling pathway

PID NCI

fra_pathway

Validated transcriptional targets of AP1 family members Fra1 and Fra2

ap1_pathway

AP-1 transcription factor network

deltanp63pathway

Validated transcriptional targets of deltaNp63 isoforms

Cross-References

SwissProt

P15408

TrEMBL

C9JCN8

UniProt Splice Variant

Entrez Gene

2355

UniGene

Hs.220971 Hs.596385 Hs.596972 Hs.639222 Hs.696748

RefSeq

NM_005253 XM_006711976 XM_006711977

HUGO

HGNC:3798

OMIM

601575

CCDS

CCDS1766

HPRD

IMGT

EMBL

AC104695 AK055579 AK302622 AK315415 BC022791 BX647822 CH471053 CR542262 X16706

GenPept

AAH22791 AAY14908 BAG37805 BAG51539 BAG63866 CAA34678 CAG47058 EAX00538 EAX00539

RNA Seq Atlas

2355