Version 5.4
Homo sapiens Gene: CPA5
Summary
InnateDB Gene IDBG-41270.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CPA5
Gene Name carboxypeptidase A5
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000158525
Encoded Proteins
IDBP-244069
carboxypeptidase A5
IDBP-386298
carboxypeptidase A5
IDBP-475922
carboxypeptidase A5
IDBP-478761
carboxypeptidase A5
IDBP-480491
carboxypeptidase A5
IDBP-476132
carboxypeptidase A5
IDBP-480309
carboxypeptidase A5
IDBP-479834
carboxypeptidase A5
IDBP-484923
carboxypeptidase A5
IDBP-483660
carboxypeptidase A5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Carboxypeptidases have functions ranging from digestion of food to selective biosynthesis of neuroendocrine peptides. Members of the A/B subfamily of carboxypeptidases, such as CPA5, contain an approximately 90-amino acid pro region that assists in the folding of the active carboxypeptidase domain. Cleavage of the pro region activates the enzyme (Wei et al., 2002 [PubMed 11836249]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:130344816-130368730
Strand Forward strand
Band q32.2
Transcripts
ENST00000393213 ENSP00000376907
ENST00000431780 ENSP00000393045
ENST00000495736
ENST00000461828 ENSP00000418183
ENST00000463587 ENSP00000420060
ENST00000497503 ENSP00000419013
ENST00000494311 ENSP00000419778
ENST00000466363 ENSP00000419025
ENST00000485477 ENSP00000420237
ENST00000474905 ENSP00000417314
ENST00000479492 ENSP00000417886
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004180 carboxypeptidase activity
GO:0004181 metallocarboxypeptidase activity
GO:0008233 peptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005576 extracellular region
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
ENSMUSG00000029788
View Gene Order
Ortholuge
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
ENSBTAG00000013476
Not yet available
Ortholuge
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.567642
RefSeq NM_001127441 NM_001127442 NM_080385 XM_005250710 XM_005250711 XM_005250712 XM_006716178
HUGO
OMIM
CCDS CCDS47713 CCDS5819
HPRD 07097
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca