Homo sapiens Gene: SFRP2
InnateDB Gene IDBG-41862.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SFRP2
Gene Name secreted frizzled-related protein 2
Synonyms FRP-2; SARP1; SDF-5
Species Homo sapiens
Ensembl Gene ENSG00000145423
Encoded Proteins
secreted frizzled-related protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:153780592-153789120
Strand Reverse strand
Band q31.3
ENST00000274063 ENSP00000274063
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001968 fibronectin binding
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0010577 metalloenzyme activator activity
GO:0017147 Wnt-protein binding
GO:0030165 PDZ domain binding
GO:0042813 Wnt-activated receptor activity
GO:0048018 receptor agonist activity
GO:0061133 endopeptidase activator activity
Biological Process
GO:0001569 patterning of blood vessels
GO:0001756 somitogenesis
GO:0001843 neural tube closure
GO:0001944 vasculature development
GO:0002063 chondrocyte development
GO:0003151 outflow tract morphogenesis
GO:0003214 cardiac left ventricle morphogenesis
GO:0006915 apoptotic process
GO:0007267 cell-cell signaling
GO:0007420 brain development
GO:0007584 response to nutrient
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0008406 gonad development
GO:0008584 male gonad development
GO:0009952 anterior/posterior pattern specification
GO:0010629 negative regulation of gene expression
GO:0010667 negative regulation of cardiac muscle cell apoptotic process
GO:0010719 negative regulation of epithelial to mesenchymal transition
GO:0010950 positive regulation of endopeptidase activity
GO:0021915 neural tube development
GO:0030111 regulation of Wnt signaling pathway
GO:0030178 negative regulation of Wnt signaling pathway
GO:0030199 collagen fibril organization
GO:0030307 positive regulation of cell growth
GO:0030308 negative regulation of cell growth
GO:0030336 negative regulation of cell migration
GO:0030514 negative regulation of BMP signaling pathway
GO:0031668 cellular response to extracellular stimulus
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0033630 positive regulation of cell adhesion mediated by integrin
GO:0035413 positive regulation of catenin import into nucleus
GO:0036342 post-anal tail morphogenesis
GO:0042127 regulation of cell proliferation
GO:0042493 response to drug
GO:0042662 negative regulation of mesodermal cell fate specification
GO:0042733 embryonic digit morphogenesis
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043508 negative regulation of JUN kinase activity
GO:0045600 positive regulation of fat cell differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0045766 positive regulation of angiogenesis
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046546 development of primary male sexual characteristics
GO:0048546 digestive tract morphogenesis
GO:0050680 negative regulation of epithelial cell proliferation
GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation
GO:0051216 cartilage development
GO:0060028 convergent extension involved in axis elongation
GO:0060349 bone morphogenesis
GO:0061056 sclerotome development
GO:0061185 negative regulation of dermatome development
GO:0071425 hematopoietic stem cell proliferation
GO:0071481 cellular response to X-ray
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090175 regulation of establishment of planar polarity
GO:0090179 planar cell polarity pathway involved in neural tube closure
GO:0090244 Wnt signaling pathway involved in somitogenesis
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:2000035 regulation of stem cell division
GO:2000041 negative regulation of planar cell polarity pathway involved in axis elongation
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0031012 extracellular matrix
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Wnt pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Signaling by WNT in cancer pathway
Signaling by Wnt pathway
Signal Transduction pathway
negative regulation of TCF-dependent signaling by WNT ligand antagonists pathway
TCF dependent signaling in response to WNT pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Disease pathway
Wnt signaling pathway pathway
Wnt signaling pathway pathway
SwissProt Q96HF1
UniProt Splice Variant
Entrez Gene 6423
UniGene Hs.481022
RefSeq NM_003013
OMIM 604157
EMBL AF017986 AF311912 AK075372 AK093922 AY359001 BC008666 CH471056
GenPept AAB70792 AAG24923 AAH08666 AAQ89360 BAG52124 BAG52787 EAX04949
RNA Seq Atlas 6423