InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: F2

Summary

InnateDB Gene

IDBG-42048.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gene Name

coagulation factor II (thrombin)

Synonyms

PT; RPRGL2; THPH1

Species

Homo sapiens

Ensembl Gene

ENSG00000180210

Encoded Proteins

IDBP-42050

coagulation factor II (thrombin)

IDBP-372661

coagulation factor II (thrombin)

IDBP-584926

coagulation factor II (thrombin)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia. [provided by RefSeq, Jul 2008]
Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:46719180-46739506

Strand

Forward strand

Band

p11.2

Transcripts

ENST00000311907	ENSP00000308541
ENST00000442468	ENSP00000387413
ENST00000469189
ENST00000490274
ENST00000530231	ENSP00000433907

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.

Experimentally validated
Total	26 [view]
Protein-Protein	25 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005102	receptor binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0008233	peptidase activity
GO:0070053	thrombospondin receptor activity

Biological Process

GO:0001934	positive regulation of protein phosphorylation
GO:0006508	proteolysis
GO:0006953	acute-phase response
GO:0007166	cell surface receptor signaling pathway
GO:0007275	multicellular organismal development
GO:0007596	blood coagulation
GO:0007597	blood coagulation, intrinsic pathway
GO:0008284	positive regulation of cell proliferation
GO:0008360	regulation of cell shape
GO:0009611	response to wounding
GO:0010468	regulation of gene expression
GO:0010544	negative regulation of platelet activation
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0017187	peptidyl-glutamic acid carboxylation
GO:0030168	platelet activation
GO:0030193	regulation of blood coagulation
GO:0030194	positive regulation of blood coagulation
GO:0030307	positive regulation of cell growth
GO:0032967	positive regulation of collagen biosynthetic process
GO:0042730	fibrinolysis
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process
GO:0045861	negative regulation of proteolysis
GO:0048712	negative regulation of astrocyte differentiation
GO:0050900	leukocyte migration
GO:0051281	positive regulation of release of sequestered calcium ion into cytosol
GO:0051480	cytosolic calcium ion homeostasis
GO:0051918	negative regulation of fibrinolysis
GO:1900738	positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway
GO:2000379	positive regulation of reactive oxygen species metabolic process

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005788	endoplasmic reticulum lumen
GO:0005796	Golgi lumen
GO:0005886	plasma membrane
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle