Homo sapiens Gene: PRKD1
Summary
InnateDB Gene IDBG-4215.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRKD1
Gene Name protein kinase D1
Synonyms PKC-MU; PKCM; PKD; PRKCM;
Species Homo sapiens
Ensembl Gene ENSG00000184304
Encoded Proteins
protein kinase D1
protein kinase D1
protein kinase D1
protein kinase D1
protein kinase D1
protein kinase D1
protein kinase D1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary PRKD1 is a serine/threonine kinase that regulates a variety of cellular functions, including membrane receptor signaling, transport at the Golgi, protection from oxidative stress at the mitochondria, gene transcription, and regulation of cell shape, motility, and adhesion (summary by Eiseler et al., 2009 [PubMed 19329994]).[supplied by OMIM, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:29576479-30191898
Strand Reverse strand
Band q12
Transcripts
ENST00000331968 ENSP00000333568
ENST00000415220 ENSP00000390535
ENST00000490795 ENSP00000447723
ENST00000468370
ENST00000546371 ENSP00000447333
ENST00000551644
ENST00000547441
ENST00000549503 ENSP00000446866
ENST00000616995 ENSP00000482645
ENST00000621126 ENSP00000483466
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 48 experimentally validated interaction(s) in this database.
Experimentally validated
Total 48 [view]
Protein-Protein 48 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004697 protein kinase C activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0001525 angiogenesis
GO:0001938 positive regulation of endothelial cell proliferation
GO:0006468 protein phosphorylation
GO:0006665 sphingolipid metabolic process
GO:0006915 apoptotic process
GO:0006954 inflammatory response
GO:0007030 Golgi organization
GO:0007165 signal transduction
GO:0007229 integrin-mediated signaling pathway
GO:0008283 cell proliferation
GO:0010595 positive regulation of endothelial cell migration
GO:0010837 regulation of keratinocyte proliferation
GO:0010976 positive regulation of neuron projection development
GO:0018105 peptidyl-serine phosphorylation
GO:0030148 sphingolipid biosynthetic process
GO:0032793 positive regulation of CREB transcription factor activity
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0034599 cellular response to oxidative stress
GO:0035556 intracellular signal transduction
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0038033 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0044281 small molecule metabolic process
GO:0045087 innate immune response
GO:0045669 positive regulation of osteoblast differentiation
GO:0045766 positive regulation of angiogenesis
GO:0045806 negative regulation of endocytosis
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046777 protein autophosphorylation
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048193 Golgi vesicle transport
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0060548 negative regulation of cell death
GO:1901727 positive regulation of histone deacetylase activity
GO:2001028 positive regulation of endothelial cell chemotaxis
GO:2001044 regulation of integrin-mediated signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005802 trans-Golgi network
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005911 cell-cell junction
GO:0005938 cell cortex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
TCR pathway
BCR pathway
REACTOME
Sphingolipid metabolism pathway
Metabolism of lipids and lipoproteins pathway
Sphingolipid de novo biosynthesis pathway
Metabolism pathway
KEGG
INOH
PID BIOCARTA
PID NCI
LPA receptor mediated events
IGF1 pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.508999 Hs.735258
RefSeq NM_002742 XM_005267859
HUGO
OMIM
CCDS CCDS9637
HPRD 05668
IMGT
EMBL
GenPept
RNA Seq Atlas