Homo sapiens Gene: ACOX2
Summary
InnateDB Gene IDBG-42297.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ACOX2
Gene Name acyl-CoA oxidase 2, branched chain
Synonyms BCOX; BRCACOX; BRCOX; THCCox;
Species Homo sapiens
Ensembl Gene ENSG00000168306
Encoded Proteins
acyl-CoA oxidase 2, branched chain
acyl-CoA oxidase 2, branched chain
acyl-CoA oxidase 2, branched chain
acyl-CoA oxidase 2, branched chain
acyl-CoA oxidase 2, branched chain
acyl-CoA oxidase 2, branched chain
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The product of this gene belongs to the acyl-CoA oxidase family. It encodes the branched-chain acyl-CoA oxidase which is involved in the degradation of long branched fatty acids and bile acid intermediates in peroxisomes. Deficiency of this enzyme results in the accumulation of branched fatty acids and bile acid intermediates, and may lead to Zellweger syndrome, severe mental retardation, and death in children. [provided by RefSeq, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:58505136-58537319
Strand Reverse strand
Band p14.3
Transcripts
ENST00000302819 ENSP00000307697
ENST00000481527
ENST00000467738
ENST00000459701 ENSP00000418562
ENST00000460921 ENSP00000417877
ENST00000489472 ENSP00000418515
ENST00000459888
ENST00000466810
ENST00000492530 ENSP00000419133
ENST00000474098 ENSP00000419927
ENST00000475143
ENST00000466689
ENST00000480791
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003995 acyl-CoA dehydrogenase activity
GO:0003997 acyl-CoA oxidase activity
GO:0005102 receptor binding
GO:0016402 pristanoyl-CoA oxidase activity
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
GO:0033791 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity
GO:0050660 flavin adenine dinucleotide binding
Biological Process
GO:0006631 fatty acid metabolic process
GO:0006635 fatty acid beta-oxidation
GO:0006699 bile acid biosynthetic process
GO:0008152 metabolic process
GO:0008206 bile acid metabolic process
GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005777 peroxisome
GO:0005782 peroxisomal matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Metabolism of lipids and lipoproteins pathway
Beta-oxidation of pristanoyl-CoA pathway
Peroxisomal lipid metabolism pathway
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol pathway
Bile acid and bile salt metabolism pathway
Synthesis of bile acids and bile salts pathway
Metabolism pathway
KEGG
Primary bile acid biosynthesis pathway
PPAR signaling pathway pathway
Peroxisome pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL C9JY29
UniProt Splice Variant
Entrez Gene 8309
UniGene Hs.444959 Hs.597766 Hs.714057
RefSeq NM_003500 XM_005265505
HUGO HGNC:120
OMIM 601641
CCDS CCDS33775
HPRD 09037
IMGT
EMBL AC116036
GenPept
RNA Seq Atlas 8309