InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ACOX2

Summary

InnateDB Gene

IDBG-42297.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACOX2

Gene Name

acyl-CoA oxidase 2, branched chain

Synonyms

BCOX; BRCACOX; BRCOX; THCCox

Species

Homo sapiens

Ensembl Gene

ENSG00000168306

Encoded Proteins

IDBP-42299

acyl-CoA oxidase 2, branched chain

IDBP-474800

acyl-CoA oxidase 2, branched chain

IDBP-479487

acyl-CoA oxidase 2, branched chain

IDBP-476694

acyl-CoA oxidase 2, branched chain

IDBP-474308

acyl-CoA oxidase 2, branched chain

IDBP-485013

acyl-CoA oxidase 2, branched chain

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The product of this gene belongs to the acyl-CoA oxidase family. It encodes the branched-chain acyl-CoA oxidase which is involved in the degradation of long branched fatty acids and bile acid intermediates in peroxisomes. Deficiency of this enzyme results in the accumulation of branched fatty acids and bile acid intermediates, and may lead to Zellweger syndrome, severe mental retardation, and death in children. [provided by RefSeq, Mar 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:58505136-58537319

Strand

Reverse strand

Band

p14.3

Transcripts

ENST00000302819	ENSP00000307697
ENST00000481527
ENST00000467738
ENST00000459701	ENSP00000418562
ENST00000460921	ENSP00000417877
ENST00000489472	ENSP00000418515
ENST00000459888
ENST00000466810
ENST00000492530	ENSP00000419133
ENST00000474098	ENSP00000419927
ENST00000475143
ENST00000466689
ENST00000480791

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003995	acyl-CoA dehydrogenase activity
GO:0003997	acyl-CoA oxidase activity
GO:0005102	receptor binding
GO:0016402	pristanoyl-CoA oxidase activity
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors
GO:0033791	3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity
GO:0050660	flavin adenine dinucleotide binding

Biological Process

GO:0006631	fatty acid metabolic process
GO:0006635	fatty acid beta-oxidation
GO:0006699	bile acid biosynthetic process
GO:0008152	metabolic process
GO:0008206	bile acid metabolic process
GO:0033540	fatty acid beta-oxidation using acyl-CoA oxidase
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005777	peroxisome
GO:0005782	peroxisomal matrix

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000021751

View Gene Order

ENSBTAG00000004178

Not yet available

Pathways

NETPATH

REACTOME

REACT_17017

Beta-oxidation of pristanoyl-CoA pathway

REACT_11041

Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol pathway

REACT_11054

Synthesis of bile acids and bile salts pathway

REACT_22258

Metabolism of lipids and lipoproteins pathway

REACT_16957

Peroxisomal lipid metabolism pathway

REACT_11040

Bile acid and bile salt metabolism pathway

REACT_111217

Metabolism pathway

KEGG

hsa03320

PPAR signaling pathway pathway

hsa00120

Primary bile acid biosynthesis pathway

hsa04146

Peroxisome pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

8309

UniGene

Hs.444959 Hs.597766 Hs.714057

RefSeq

NM_003500 XM_005265505

HUGO

HGNC:120

OMIM

601641

CCDS

CCDS33775

HPRD

09037

IMGT

EMBL

GenPept

RNA Seq Atlas

8309