Version 5.4
Homo sapiens Gene: IDH3B
Summary
InnateDB Gene IDBG-42307.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IDH3B
Gene Name isocitrate dehydrogenase 3 (NAD+) beta
Synonyms H-IDHB; RP46
Species Homo sapiens
Ensembl Gene ENSG00000101365
Encoded Proteins
IDBP-42311
isocitrate dehydrogenase 3 (NAD+) beta
IDBP-42313
isocitrate dehydrogenase 3 (NAD+) beta
IDBP-810157
isocitrate dehydrogenase 3 (NAD+) beta
IDBP-810168
isocitrate dehydrogenase 3 (NAD+) beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the beta subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:2658395-2664219
Strand Reverse strand
Band p13
Transcripts
ENST00000380843 ENSP00000370223
ENST00000380851 ENSP00000370232
ENST00000474315 ENSP00000482773
ENST00000466494
ENST00000492240
ENST00000488299
ENST00000477689
ENST00000466999
ENST00000479376
ENST00000462967
ENST00000491065
ENST00000613370 ENSP00000484922
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 9 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0004449 isocitrate dehydrogenase (NAD+) activity
GO:0009055 electron carrier activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0051287 NAD binding
Biological Process
GO:0006099 tricarboxylic acid cycle
GO:0006102 isocitrate metabolic process
GO:0006103 2-oxoglutarate metabolic process
GO:0006734 NADH metabolic process
GO:0044237 cellular metabolic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027406
View Gene Order
ENSBTAG00000018813
Not yet available
Pathways
NETPATH
REACTOME
REACT_1785
Citric acid cycle (TCA cycle) pathway
REACT_1046
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
REACT_111083
The citric acid (TCA) cycle and respiratory electron transport pathway
REACT_111217
Metabolism pathway
KEGG
hsa00020
Citrate cycle (TCA cycle) pathway
INOH
INOH website
Citrate cycle pathway
PID NCI
Cross-References
SwissProt
TrEMBL B4DU38 Q9UIC5
UniProt Splice Variant
Entrez Gene 3420
UniGene
RefSeq XM_005260716 NM_001258384 NM_006899 NM_174855
HUGO HGNC:5385
OMIM 604526
CCDS CCDS13031 CCDS13032 CCDS74696
HPRD
IMGT
EMBL AF023265 AF023266 AF046929 AK001905 AK300485 AK315641 AL049712 AL050094 BC001960 CH471133 U49283
GenPept AAB94295 AAD09339 AAD09340 AAF20164 AAH01960 BAA91971 BAG38008 BAG62200 CAB43266 CAC01442 CAC01443 EAX10579 EAX10580 EAX10582 EAX10583
RNA Seq Atlas 3420

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca