Homo sapiens Gene: IDH3B
Summary
InnateDB Gene IDBG-42307.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IDH3B
Gene Name isocitrate dehydrogenase 3 (NAD+) beta
Synonyms H-IDHB; RP46;
Species Homo sapiens
Ensembl Gene ENSG00000101365
Encoded Proteins
isocitrate dehydrogenase 3 (NAD+) beta
isocitrate dehydrogenase 3 (NAD+) beta
isocitrate dehydrogenase 3 (NAD+) beta
isocitrate dehydrogenase 3 (NAD+) beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the beta subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:2658395-2664219
Strand Reverse strand
Band p13
Transcripts
ENST00000380843 ENSP00000370223
ENST00000380851 ENSP00000370232
ENST00000474315 ENSP00000482773
ENST00000466494
ENST00000492240
ENST00000488299
ENST00000477689
ENST00000466999
ENST00000479376
ENST00000462967
ENST00000491065
ENST00000613370 ENSP00000484922
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 9 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0004449 isocitrate dehydrogenase (NAD+) activity
GO:0009055 electron carrier activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0051287 NAD binding
Biological Process
GO:0006099 tricarboxylic acid cycle
GO:0006102 isocitrate metabolic process
GO:0006103 2-oxoglutarate metabolic process
GO:0006734 NADH metabolic process
GO:0044237 cellular metabolic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
Citric acid cycle (TCA cycle) pathway
The citric acid (TCA) cycle and respiratory electron transport pathway
Metabolism pathway
KEGG
Citrate cycle (TCA cycle) pathway
INOH
Citrate cycle pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.436405 Hs.667359
RefSeq NM_001258384 NM_006899 NM_174855 XM_005260716
HUGO
OMIM
CCDS CCDS13031 CCDS13032 CCDS74696
HPRD 05163
IMGT
EMBL
GenPept
RNA Seq Atlas