InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GUCY1B3

Summary

InnateDB Gene

IDBG-42428.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GUCY1B3

Gene Name

guanylate cyclase 1, soluble, beta 3

Synonyms

GC-S-beta-1; GC-SB3; GUC1B3; GUCB3; GUCSB3; GUCY1B1

Species

Homo sapiens

Ensembl Gene

ENSG00000061918

Encoded Proteins

IDBP-42430

guanylate cyclase 1, soluble, beta 3

IDBP-476506

guanylate cyclase 1, soluble, beta 3

IDBP-482370

guanylate cyclase 1, soluble, beta 3

IDBP-481338

guanylate cyclase 1, soluble, beta 3

IDBP-474978

guanylate cyclase 1, soluble, beta 3

IDBP-475374

guanylate cyclase 1, soluble, beta 3

IDBP-475743

guanylate cyclase 1, soluble, beta 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha subunit and a beta subunit, typically GUCY1B3, catalyzes conversion of GTP to the second messenger cGMP and functions as the main receptor for nitric oxide (NO) and nitrovasodilator drugs (Zabel et al., 1998 [PubMed 9742212]).[supplied by OMIM, Mar 2008]
This gene encodes the beta subunit of the soluble guanylate cyclase (sGC), which catalyzes the conversion of GTP (guanosine triphosphate) to cGMP (cyclic guanosine monophosphate). The encoded protein contains an HNOX domain, which serves as a receptor for ligands such as nitric oxide, oxygen and nitrovasodilator drugs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:155758992-155807591

Strand

Forward strand

Band

q32.1

Transcripts

ENST00000264424	ENSP00000264424
ENST00000505154	ENSP00000427226
ENST00000502959	ENSP00000426786
ENST00000505764	ENSP00000426319
ENST00000507146	ENSP00000422313
ENST00000503520	ENSP00000420842
ENST00000513437	ENSP00000425065

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	9 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004383	guanylate cyclase activity
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0016849	phosphorus-oxygen lyase activity
GO:0020037	heme binding
GO:0043167	ion binding
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity
GO:0051879	Hsp90 protein binding

Biological Process

GO:0006182	cGMP biosynthetic process
GO:0007263	nitric oxide mediated signal transduction
GO:0007596	blood coagulation
GO:0008015	blood circulation
GO:0009190	cyclic nucleotide biosynthetic process
GO:0035556	intracellular signal transduction

Cellular Component

GO:0005737	cytoplasm
GO:0008074	guanylate cyclase complex, soluble
GO:0043231	intracellular membrane-bounded organelle
GO:0043234	protein complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000028005

View Gene Order

ENSBTAG00000003840

Not yet available

Pathways

NETPATH

REACTOME

REACT_23862

Nitric oxide stimulates guanylate cyclase pathway

REACT_23876

Platelet homeostasis pathway

REACT_604

Hemostasis pathway

KEGG

hsa04540

Gap junction pathway

hsa00230

Purine metabolism pathway

hsa04730

Long-term depression pathway

hsa04270

Vascular smooth muscle contraction pathway

hsa04970

Salivary secretion pathway

INOH

INOH website

Purine nucleotides nucleosides metabolism pathway

PID NCI

Cross-References

SwissProt

TrEMBL

E9PCN2

UniProt Splice Variant

Entrez Gene

2983

UniGene

Hs.77890

RefSeq

NM_000857 NM_001291952 NM_001291953 NM_001291954 NM_001291955 XM_005262959

HUGO

HGNC:4687

OMIM

139397

CCDS

CCDS47154 CCDS75203

HPRD

00769

IMGT

EMBL

AC114761

GenPept

RNA Seq Atlas

2983