Version 5.4
Homo sapiens Gene: BCAR1
Summary
InnateDB Gene IDBG-42468.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BCAR1
Gene Name breast cancer anti-estrogen resistance 1
Synonyms CAS; CAS1; CASS1; CRKAS; P130Cas
Species Homo sapiens
Ensembl Gene ENSG00000050820
Encoded Proteins
IDBP-42470
breast cancer anti-estrogen resistance 1
IDBP-243647
breast cancer anti-estrogen resistance 1
IDBP-243649
breast cancer anti-estrogen resistance 1
IDBP-380873
breast cancer anti-estrogen resistance 1
IDBP-380874
breast cancer anti-estrogen resistance 1
IDBP-600469
breast cancer anti-estrogen resistance 1
IDBP-587632
breast cancer anti-estrogen resistance 1
IDBP-597145
breast cancer anti-estrogen resistance 1
IDBP-598666
breast cancer anti-estrogen resistance 1
IDBP-754424
IDBP-749411
IDBP-750216
IDBP-745287
IDBP-747283
IDBP-752688
IDBP-751135
IDBP-750509
IDBP-754212
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 17129785
BCAR1 acts as a primary force sensor, transducing force into mechanical extension and thereby priming phosphorylation and activation of downstream signalling whereby tyrosine phosphorylation of BCRA1 in a cytoskeletal complex is involved in force-dependent activation of the small GTPase RAP1A.
Entrez Gene
Summary BCAR1, or CAS, is an Src (MIM 190090) family kinase substrate involved in various cellular events, including migration, survival, transformation, and invasion (Sawada et al., 2006 [PubMed 17129785]).[supplied by OMIM, May 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:75228187-75268053
Strand Reverse strand
Band q23.1
Transcripts
ENST00000162330 ENSP00000162330
ENST00000393422 ENSP00000377074
ENST00000393420 ENSP00000377072
ENST00000420641 ENSP00000392708
ENST00000418647 ENSP00000391669
ENST00000538440 ENSP00000443841
ENST00000535626 ENSP00000440370
ENST00000542031 ENSP00000440415
ENST00000546196 ENSP00000442161
ENST00000568864 ENSP00000456625
ENST00000564170
ENST00000561970 ENSP00000457457
ENST00000567215 ENSP00000457231
ENST00000562556 ENSP00000455166
ENST00000566982
ENST00000564028 ENSP00000455810
ENST00000569006 ENSP00000458088
ENST00000563700
ENST00000563323 ENSP00000457097
ENST00000563038
ENST00000566465 ENSP00000456929
ENST00000569340 ENSP00000454702
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 105 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 105 [view]
Protein-Protein 103 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0017124 SH3 domain binding
GO:0019901 protein kinase binding
Biological Process
GO:0001558 regulation of cell growth
GO:0007015 actin filament organization
GO:0007155 cell adhesion
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007229 integrin-mediated signaling pathway
GO:0007596 blood coagulation
GO:0008283 cell proliferation
GO:0008286 insulin receptor signaling pathway
GO:0010595 positive regulation of endothelial cell migration
GO:0016477 cell migration
GO:0030168 platelet activation
GO:0030335 positive regulation of cell migration
GO:0035729 cellular response to hepatocyte growth factor stimulus
GO:0042981 regulation of apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048012 hepatocyte growth factor receptor signaling pathway
GO:0050851 antigen receptor-mediated signaling pathway
GO:0050852 T cell receptor signaling pathway
GO:0050853 B cell receptor signaling pathway
GO:0051301 cell division
GO:0060326 cell chemotaxis
Cellular Component
GO:0001726 ruffle
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0030027 lamellipodium
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031955
View Gene Order
ENSBTAG00000012002
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
NetPath_7
TGF_beta_Receptor pathway
NetPath_12
BCR pathway
REACTOME
REACT_15381
p130Cas linkage to MAPK signaling for integrins pathway
REACT_15523
Integrin alphaIIb beta3 signaling pathway
REACT_278
Platelet Aggregation (Plug Formation) pathway
REACT_17025
Downstream signal transduction pathway
REACT_16888
Signaling by PDGF pathway
REACT_12529
Signaling by VEGF pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_111102
Signal Transduction pathway
REACT_228166
VEGFA-VEGFR2 Pathway pathway
REACT_604
Hemostasis pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04670
Leukocyte transendothelial migration pathway
hsa04510
Focal adhesion pathway
hsa04062
Chemokine signaling pathway pathway
hsa05100
Bacterial invasion of epithelial cells pathway
INOH
INOH website
Integrin signaling pathway pathway
PID NCI
met_pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
lysophospholipid_pathway
LPA receptor mediated events
cxcr4_pathway
CXCR4-mediated signaling events
netrin_pathway
Netrin-mediated signaling events
avb3_integrin_pathway
Integrins in angiogenesis
ptp1bpathway
Signaling events mediated by PTP1B
upa_upar_pathway
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
integrin_a9b1_pathway
Alpha9 beta1 integrin signaling events
fak_pathway
Signaling events mediated by focal adhesion kinase
igf1_pathway
IGF1 pathway
rac1_pathway
RAC1 signaling pathway
endothelinpathway
Endothelins
prlsignalingeventspathway
Signaling events mediated by PRL
cdc42_pathway
CDC42 signaling events
er_nongenomic_pathway
Plasma membrane estrogen receptor signaling
ret_pathway
Signaling events regulated by Ret tyrosine kinase
integrin_a4b1_pathway
Alpha4 beta1 integrin signaling events
epha2_fwdpathway
EPHA2 forward signaling
pdgfrbpathway
PDGFR-beta signaling pathway
avb3_opn_pathway
Osteopontin-mediated events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.479747
RefSeq NM_001170714 NM_001170715 NM_001170716 NM_001170717 NM_001170718 NM_001170719 NM_001170720 NM_014567 XM_005256258 XM_005256259 XM_005256260 XM_006721348
HUGO
OMIM
CCDS CCDS10915 CCDS54037 CCDS54038 CCDS54039 CCDS54040 CCDS54041 CCDS54042 CCDS54043
HPRD 04248
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca