Version 5.4
Homo sapiens Gene: TERF2IP
Summary
InnateDB Gene IDBG-42783.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TERF2IP
Gene Name telomeric repeat binding factor 2, interacting protein
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000166848
Encoded Proteins
IDBP-42785
telomeric repeat binding factor 2, interacting protein
IDBP-752102
IDBP-750244
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The gene encodes a protein that is part of a complex involved in telomere length regulation. Pseudogenes are present on chromosomes 5 and 22. [provided by RefSeq, Apr 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:75647786-75761872
Strand Forward strand
Band q23.1
Transcripts
ENST00000300086 ENSP00000300086
ENST00000569234 ENSP00000454399
ENST00000564671 ENSP00000456092
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 163 experimentally validated interaction(s) in this database.
Experimentally validated
Total 163 [view]
Protein-Protein 162 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
Biological Process
GO:0000723 telomere maintenance
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007004 telomere maintenance via telomerase
GO:0010569 regulation of double-strand break repair via homologous recombination
GO:0010833 telomere maintenance via telomere lengthening
GO:0031848 protection from non-homologous end joining at telomere
GO:0032205 negative regulation of telomere maintenance
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0048239 negative regulation of DNA recombination at telomere
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0070198 protein localization to chromosome, telomeric region
Cellular Component
GO:0000228 nuclear chromosome
GO:0000781 chromosome, telomeric region
GO:0000783 nuclear telomere cap complex
GO:0000784 nuclear chromosome, telomeric region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0030870 Mre11 complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000033430
View Gene Order
ENSBTAG00000015686
Not yet available
Pathways
NETPATH
REACTOME
REACT_75792
Meiotic synapsis pathway
REACT_7963
Packaging Of Telomere Ends pathway
REACT_120956
Cellular responses to stress pathway
REACT_22172
Chromosome Maintenance pathway
REACT_7970
Telomere Maintenance pathway
REACT_115566
Cell Cycle pathway
REACT_169185
DNA Damage/Telomere Stress Induced Senescence pathway
REACT_169274
Cellular Senescence pathway
REACT_111183
Meiosis pathway
KEGG
INOH
PID NCI
telomerasepathway
Regulation of Telomerase
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.301419
RefSeq NM_018975
HUGO
OMIM
CCDS CCDS32491
HPRD 05452
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca