InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: DDIT3

Summary

InnateDB Gene

IDBG-42805.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DDIT3

Gene Name

DNA-damage-inducible transcript 3

Synonyms

CEBPZ; CHOP; CHOP-10; CHOP10; GADD153

Species

Homo sapiens

Ensembl Gene

ENSG00000175197

Encoded Proteins

IDBP-42807

DNA-damage-inducible transcript 3

IDBP-603073

DNA-damage-inducible transcript 3

IDBP-592856

DNA-damage-inducible transcript 3

IDBP-591966

DNA-damage-inducible transcript 3

IDBP-590258

DNA-damage-inducible transcript 3

IDBP-809540

DNA-damage-inducible transcript 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 20876114

DDIT3 (CHOP) is an endoplasmic reticulum (ER) stress-induced transcription factor that targets the IL23 gene and this binding is enhanced in the context of both ER stress and Toll-like receptor (TLR) stimulation.

Entrez Gene

Summary

This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified. [provided by RefSeq, Aug 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:57516588-57520517

Strand

Reverse strand

Band

q13.3

Transcripts

ENST00000346473	ENSP00000340671
ENST00000547303	ENSP00000447188
ENST00000551116	ENSP00000448665
ENST00000552740	ENSP00000447803
ENST00000547526	ENSP00000447503
ENST00000623876
ENST00000618206	ENSP00000481270

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 88 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	88 [view]
Protein-Protein	80 [view]
Protein-DNA	8 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001955	blood vessel maturation
GO:0006355	regulation of transcription, DNA-templated
GO:0006915	apoptotic process
GO:0006974	cellular response to DNA damage stimulus
GO:0006983	ER overload response
GO:0006986	response to unfolded protein
GO:0006987	activation of signaling protein activity involved in unfolded protein response
GO:0007050	cell cycle arrest
GO:0016055	Wnt signaling pathway
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0032757	positive regulation of interleukin-8 production
GO:0034976	response to endoplasmic reticulum stress
GO:0042594	response to starvation
GO:0042789	mRNA transcription from RNA polymerase II promoter
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043525	positive regulation of neuron apoptotic process
GO:0043620	regulation of DNA-dependent transcription in response to stress
GO:0044267	cellular protein metabolic process
GO:0044324	regulation of transcription involved in anterior/posterior axis specification
GO:0045087	innate immune response (InnateDB)
GO:0045454	cell redox homeostasis
GO:0045662	negative regulation of myoblast differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051209	release of sequestered calcium ion into cytosol
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:2000016	negative regulation of determination of dorsal identity

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005770	late endosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000025408

View Gene Order

ENSBTAG00000031544

Not yet available

Pathways

NETPATH

REACTOME

REACT_18355

ATF4 activates genes pathway

REACT_18277

PERK regulates gene expression pathway

REACT_18423

ATF6-alpha activates chaperone genes pathway

REACT_18348

ATF6-alpha activates chaperones pathway

REACT_18356

Unfolded Protein Response (UPR) pathway

REACT_17015

Metabolism of proteins pathway

KEGG

hsa04010

MAPK signaling pathway pathway

hsa04141

Protein processing in endoplasmic reticulum pathway

INOH

PID NCI

atf2_pathway

ATF-2 transcription factor network

myc_represspathway

Validated targets of C-MYC transcriptional repression

p38alphabetadownstreampathway

Signaling mediated by p38-alpha and p38-beta

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.505777

RefSeq

NM_001195053 NM_001195054 NM_001195055 NM_001195056 NM_001195057 NM_004083

HUGO

OMIM

CCDS

CCDS55838 CCDS8943

HPRD

00529

IMGT

EMBL

GenPept

RNA Seq Atlas