Homo sapiens Gene: KIF5A
Summary
InnateDB Gene IDBG-42948.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KIF5A
Gene Name kinesin family member 5A
Synonyms D12S1889; MY050; NKHC; SPG10;
Species Homo sapiens
Ensembl Gene ENSG00000155980
Encoded Proteins
kinesin family member 5A
kinesin family member 5A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the kinesin family of proteins. Members of this family are part of a multisubunit complex that functions as a microtubule motor in intracellular organelle transport. Mutations in this gene cause autosomal dominant spastic paraplegia 10. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:57549998-57586632
Strand Forward strand
Band q13.3
Transcripts
ENST00000286452 ENSP00000286452
ENST00000455537 ENSP00000408979
ENST00000552227
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 28 [view]
Protein-Protein 28 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003774 motor activity
GO:0003777 microtubule motor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008017 microtubule binding
Biological Process
GO:0007018 microtubule-based movement
GO:0007268 synaptic transmission
GO:0007596 blood coagulation
GO:0008152 metabolic process
GO:0008219 cell death
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
Cellular Component
GO:0005829 cytosol
GO:0005871 kinesin complex
GO:0005874 microtubule
GO:0016020 membrane
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
MHC class II antigen presentation pathway
Kinesins pathway
Metabolism of proteins pathway
Adaptive Immune System pathway
Immune System pathway
Insulin processing pathway
Factors involved in megakaryocyte development and platelet production pathway
Peptide hormone metabolism pathway
Hemostasis pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.151219 Hs.628372 Hs.713130
RefSeq NM_004984
HUGO
OMIM
CCDS CCDS8945
HPRD 09108
IMGT
EMBL
GenPept
RNA Seq Atlas