Homo sapiens Gene: OSBP2 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Gene | IDBG-4309.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | OSBP2 | ||||||||||||||||||
Gene Name | oxysterol binding protein 2 | ||||||||||||||||||
Synonyms | HLM; ORP-4; ORP4; OSBPL1; OSBPL4 | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Gene | ENSG00000184792 | ||||||||||||||||||
Encoded Proteins |
oxysterol binding protein 2
oxysterol binding protein 2
oxysterol binding protein 2
oxysterol binding protein 2
oxysterol binding protein 2
oxysterol binding protein 2
oxysterol binding protein 2
oxysterol binding protein 2
oxysterol binding protein 2
oxysterol binding protein 2
oxysterol binding protein 2
oxysterol binding protein 2
oxysterol binding protein 2
oxysterol binding protein 2
oxysterol binding protein 2
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Protein Structure | |||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
Entrez Gene | |||||||||||||||||||
Summary |
Oxysterols are byproducts of cholesterol that can have cytotoxic effects on many cell types. The membrane-bound protein encoded by this gene contains a pleckstrin homology (PH) domain and an oxysterol-binding region. It binds oxysterols such as 7-ketocholesterol and may inhibit their cytotoxicity. Alternate transcriptional splice variants have been observed but have not been fully characterized. [provided by RefSeq, Jul 2008] The protein encoded by this gene contains a pleckstrin homology (PH) domain and an oxysterol-binding region. It binds oxysterols such as 7-ketocholesterol and may inhibit their cytotoxicity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2013] |
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Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome 22:30693782-30907824 | ||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||
Band | q12.2 | ||||||||||||||||||
Transcripts | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Cross-References | |||||||||||||||||||
SwissProt | |||||||||||||||||||
TrEMBL | C9J7J0 | ||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 23762 | ||||||||||||||||||
UniGene | Hs.517546 Hs.615076 Hs.734124 | ||||||||||||||||||
RefSeq | NM_001282738 NM_001282739 NM_001282740 NM_001282741 NM_001282742 NM_030758 XM_006724204 XM_006724205 XM_006724206 XM_006724207 XM_006724208 XM_006724209 | ||||||||||||||||||
HUGO | HGNC:8504 | ||||||||||||||||||
OMIM | 606729 | ||||||||||||||||||
CCDS | CCDS43002 CCDS63448 CCDS63449 CCDS63450 CCDS63451 | ||||||||||||||||||
HPRD | 09471 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AC004542 AL022336 AL079299 | ||||||||||||||||||
GenPept | |||||||||||||||||||
RNA Seq Atlas | 102725085 23762 | ||||||||||||||||||