Homo sapiens Gene: OSBP2
Summary
InnateDB Gene IDBG-4309.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol OSBP2
Gene Name oxysterol binding protein 2
Synonyms HLM; ORP-4; ORP4; OSBPL1; OSBPL4;
Species Homo sapiens
Ensembl Gene ENSG00000184792
Encoded Proteins
oxysterol binding protein 2
oxysterol binding protein 2
oxysterol binding protein 2
oxysterol binding protein 2
oxysterol binding protein 2
oxysterol binding protein 2
oxysterol binding protein 2
oxysterol binding protein 2
oxysterol binding protein 2
oxysterol binding protein 2
oxysterol binding protein 2
oxysterol binding protein 2
oxysterol binding protein 2
oxysterol binding protein 2
oxysterol binding protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Oxysterols are byproducts of cholesterol that can have cytotoxic effects on many cell types. The membrane-bound protein encoded by this gene contains a pleckstrin homology (PH) domain and an oxysterol-binding region. It binds oxysterols such as 7-ketocholesterol and may inhibit their cytotoxicity. Alternate transcriptional splice variants have been observed but have not been fully characterized. [provided by RefSeq, Jul 2008]
The protein encoded by this gene contains a pleckstrin homology (PH) domain and an oxysterol-binding region. It binds oxysterols such as 7-ketocholesterol and may inhibit their cytotoxicity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:30693782-30907824
Strand Forward strand
Band q12.2
Transcripts
ENST00000332585 ENSP00000332576
ENST00000407373 ENSP00000385237
ENST00000403222 ENSP00000384213
ENST00000401475 ENSP00000385254
ENST00000438716 ENSP00000411052
ENST00000437268 ENSP00000389200
ENST00000446658 ENSP00000392080
ENST00000445781 ENSP00000411497
ENST00000424224 ENSP00000388575
ENST00000431368 ENSP00000415274
ENST00000453621 ENSP00000401776
ENST00000454145 ENSP00000409011
ENST00000452656 ENSP00000409838
ENST00000433183 ENSP00000392362
ENST00000477355
ENST00000464341
ENST00000496367
ENST00000496575
ENST00000535268 ENSP00000438713
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0015485 cholesterol binding
Biological Process
GO:0006869 lipid transport
Cellular Component
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.517546 Hs.615076 Hs.734124
RefSeq NM_001282738 NM_001282739 NM_001282740 NM_001282741 NM_001282742 NM_030758 XM_006724204 XM_006724205 XM_006724206 XM_006724207 XM_006724208 XM_006724209
HUGO
OMIM
CCDS CCDS43002 CCDS63448 CCDS63449 CCDS63450 CCDS63451
HPRD 09471
IMGT
EMBL
GenPept
RNA Seq Atlas