Version 5.4
Homo sapiens Gene: UQCRQ
Summary
InnateDB Gene IDBG-43592.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UQCRQ
Gene Name ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000164405
Encoded Proteins
IDBP-43594
ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa
IDBP-43596
ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa
IDBP-43598
ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a ubiquinone-binding protein of low molecular mass. This protein is a small core-associated protein and a subunit of ubiquinol-cytochrome c reductase complex III, which is part of the mitochondrial respiratory chain. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:132866560-132868031
Strand Forward strand
Band q31.1
Transcripts
ENST00000378670 ENSP00000367939
ENST00000378667 ENSP00000367936
ENST00000378665 ENSP00000367934
ENST00000498309
ENST00000496429
ENST00000480372
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 14 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008121 ubiquinol-cytochrome-c reductase activity
Biological Process
GO:0021539 subthalamus development
GO:0021548 pons development
GO:0021680 cerebellar Purkinje cell layer development
GO:0021766 hippocampus development
GO:0021794 thalamus development
GO:0021854 hypothalamus development
GO:0021860 pyramidal neuron development
GO:0022904 respiratory electron transport chain
GO:0030901 midbrain development
GO:0044237 cellular metabolic process
GO:0044281 small molecule metabolic process
GO:1902600 hydrogen ion transmembrane transport
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0070469 respiratory chain
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000044894
View Gene Order
ENSBTAG00000009479
Not yet available
Pathways
NETPATH
REACTOME
REACT_22393
Respiratory electron transport pathway
REACT_6305
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. pathway
REACT_111083
The citric acid (TCA) cycle and respiratory electron transport pathway
REACT_111217
Metabolism pathway
KEGG
hsa05010
Alzheimer's disease pathway
hsa00190
Oxidative phosphorylation pathway
hsa05012
Parkinson's disease pathway
hsa05016
Huntington's disease pathway
hsa04260
Cardiac muscle contraction pathway
INOH
PID NCI
Cross-References
SwissProt O14949
TrEMBL
UniProt Splice Variant
Entrez Gene 27089
UniGene Hs.146602 Hs.644948
RefSeq NM_014402
HUGO HGNC:29594
OMIM 612080
CCDS CCDS34237
HPRD
IMGT
EMBL BC001390 BC090048 D50369
GenPept AAH01390 AAH90048 BAA23321
RNA Seq Atlas 27089

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca