Homo sapiens Gene: VPS4B
Summary
InnateDB Gene IDBG-4397.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VPS4B
Gene Name vacuolar protein sorting 4 homolog B (S. cerevisiae)
Synonyms SKD1; SKD1B; VPS4-2;
Species Homo sapiens
Ensembl Gene ENSG00000119541
Encoded Proteins
vacuolar protein sorting 4 homolog B (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. Mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be a yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 18; the gene for the other resides on chromosome 16. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:63389190-63422483
Strand Reverse strand
Band q21.33
Transcripts
ENST00000238497 ENSP00000238497
ENST00000588323
ENST00000588059 ENSP00000465944
ENST00000591519 ENSP00000465846
ENST00000591475
ENST00000591383
ENST00000589604
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 31 [view]
Protein-Protein 30 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0009378 four-way junction helicase activity
GO:0016887 ATPase activity
GO:0042623 ATPase activity, coupled
Biological Process
GO:0006200 ATP catabolic process
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0006813 potassium ion transport
GO:0007032 endosome organization
GO:0007049 cell cycle
GO:0015031 protein transport
GO:0016032 viral process
GO:0016197 endosomal transport
GO:0019058 viral life cycle
GO:0030301 cholesterol transport
GO:0032367 intracellular cholesterol transport
GO:0032510 endosome to lysosome transport via multivesicular body sorting pathway
GO:0033993 response to lipid
GO:0050792 regulation of viral process
GO:0051301 cell division
GO:0061024 membrane organization
GO:1902188 positive regulation of viral release from host cell
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005768 endosome
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005774 vacuolar membrane
GO:0005829 cytosol
GO:0010008 endosome membrane
GO:0031902 late endosome membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Late Phase of HIV Life Cycle pathway
Endosomal Sorting Complex Required For Transport (ESCRT) pathway
HIV Life Cycle pathway
HIV Infection pathway
Budding and maturation of HIV virion pathway
Disease pathway
Membrane Trafficking pathway
KEGG
Endocytosis pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.126550
RefSeq NM_004869
HUGO
OMIM
CCDS CCDS11983
HPRD 15653
IMGT
EMBL
GenPept
RNA Seq Atlas