Homo sapiens Gene: PRPS2
Summary
InnateDB Gene IDBG-44129.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRPS2
Gene Name phosphoribosyl pyrophosphate synthetase 2
Synonyms PRSII;
Species Homo sapiens
Ensembl Gene ENSG00000101911
Encoded Proteins
phosphoribosyl pyrophosphate synthetase 2
phosphoribosyl pyrophosphate synthetase 2
phosphoribosyl pyrophosphate synthetase 2
phosphoribosyl pyrophosphate synthetase 2
phosphoribosyl pyrophosphate synthetase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a phosphoribosyl pyrophosphate synthetase that plays a central role in the synthesis of purines and pyrimidines. The encoded protein catalyzes the synthesis of 5-phosphoribosyl 1-pyrophosphate from ATP and D-ribose 5-phosphate. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome X:12791355-12824222
Strand Forward strand
Band p22.2
Transcripts
ENST00000380668 ENSP00000370043
ENST00000380663 ENSP00000370038
ENST00000398491 ENSP00000381504
ENST00000489404 ENSP00000419380
ENST00000461630 ENSP00000418911
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 12 [view]
Protein-DNA 2 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0004749 ribose phosphate diphosphokinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016208 AMP binding
GO:0016301 kinase activity
GO:0019003 GDP binding
GO:0030246 carbohydrate binding
GO:0042803 protein homodimerization activity
GO:0043531 ADP binding
Biological Process
GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006167 AMP biosynthetic process
GO:0009116 nucleoside metabolic process
GO:0009156 ribonucleoside monophosphate biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0016310 phosphorylation
GO:0019693 ribose phosphate metabolic process
GO:0031100 organ regeneration
Cellular Component
GO:0002189 ribose phosphate diphosphokinase complex
GO:0043234 protein complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
Myoclonic epilepsy of Lafora pathway
Metabolism of carbohydrates pathway
5-Phosphoribose 1-diphosphate biosynthesis pathway
Metabolism pathway
Disease pathway
Glycogen storage diseases pathway
KEGG
Pentose phosphate pathway pathway
Purine metabolism pathway
INOH
Pentose phosphate cycle pathway
Purine nucleotides nucleosides metabolism pathway
Pyrimidine nucleotides nucleosides metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.654581 Hs.672215
RefSeq NM_001039091 NM_002765
HUGO
OMIM
CCDS CCDS14150 CCDS43918
HPRD 02414
IMGT
EMBL
GenPept
RNA Seq Atlas