InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PRPS2

Summary

InnateDB Gene

IDBG-44129.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRPS2

Gene Name

phosphoribosyl pyrophosphate synthetase 2

Synonyms

PRSII

Species

Homo sapiens

Ensembl Gene

ENSG00000101911

Encoded Proteins

IDBP-44131

phosphoribosyl pyrophosphate synthetase 2

IDBP-44133

phosphoribosyl pyrophosphate synthetase 2

IDBP-232949

phosphoribosyl pyrophosphate synthetase 2

IDBP-474400

phosphoribosyl pyrophosphate synthetase 2

IDBP-478208

phosphoribosyl pyrophosphate synthetase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a phosphoribosyl pyrophosphate synthetase that plays a central role in the synthesis of purines and pyrimidines. The encoded protein catalyzes the synthesis of 5-phosphoribosyl 1-pyrophosphate from ATP and D-ribose 5-phosphate. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:12791355-12824222

Strand

Forward strand

Band

p22.2

Transcripts

ENST00000380668	ENSP00000370043
ENST00000380663	ENSP00000370038
ENST00000398491	ENSP00000381504
ENST00000489404	ENSP00000419380
ENST00000461630	ENSP00000418911

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.

Experimentally validated
Total	15 [view]
Protein-Protein	12 [view]
Protein-DNA	2 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004749	ribose phosphate diphosphokinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016208	AMP binding
GO:0016301	kinase activity
GO:0019003	GDP binding
GO:0030246	carbohydrate binding
GO:0042803	protein homodimerization activity
GO:0043531	ADP binding

Biological Process

GO:0006015	5-phosphoribose 1-diphosphate biosynthetic process
GO:0006139	nucleobase-containing compound metabolic process
GO:0006167	AMP biosynthetic process
GO:0009116	nucleoside metabolic process
GO:0009156	ribonucleoside monophosphate biosynthetic process
GO:0009165	nucleotide biosynthetic process
GO:0016310	phosphorylation
GO:0019693	ribose phosphate metabolic process
GO:0031100	organ regeneration