Version 5.4
Homo sapiens Gene: AGK
Summary
InnateDB Gene IDBG-44452.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AGK
Gene Name acylglycerol kinase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000006530
Encoded Proteins
IDBP-44454
acylglycerol kinase
IDBP-473665
acylglycerol kinase
IDBP-475838
acylglycerol kinase
IDBP-478041
acylglycerol kinase
IDBP-482403
acylglycerol kinase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a mitochondrial membrane protein involved in lipid and glycerolipid metabolism. The encoded protein is a lipid kinase that catalyzes the formation of phosphatidic and lysophosphatidic acids. Defects in this gene have been associated with mitochondrial DNA depletion syndrome 10. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:141551189-141655244
Strand Forward strand
Band q34
Transcripts
ENST00000355413 ENSP00000347581
ENST00000473247 ENSP00000420776
ENST00000495028
ENST00000473884 ENSP00000420540
ENST00000492693 ENSP00000418789
ENST00000494688 ENSP00000418101
ENST00000465241
ENST00000496784
ENST00000496273
ENST00000494053
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001727 lipid kinase activity
GO:0001729 ceramide kinase activity
GO:0003951 NAD+ kinase activity
GO:0004143 diacylglycerol kinase activity
GO:0005524 ATP binding
GO:0047620 acylglycerol kinase activity
Biological Process
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0016310 phosphorylation
GO:0046486 glycerolipid metabolic process
GO:0046513 ceramide biosynthetic process
GO:0046834 lipid phosphorylation
Cellular Component
GO:0005739 mitochondrion
GO:0016020 membrane
GO:0031966 mitochondrial membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029916
View Gene Order
ENSBTAG00000019265
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00561
Glycerolipid metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.685880 Hs.733211 Hs.743318
RefSeq NM_018238 XM_005250021
HUGO
OMIM
CCDS CCDS5865
HPRD 08554
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca