InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: EGLN3

Summary

InnateDB Gene

IDBG-4515.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EGLN3

Gene Name

egl nine homolog 3 (C. elegans)

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000129521

Encoded Proteins

IDBP-4517

egl nine homolog 3 (C. elegans)

IDBP-601699

egl nine homolog 3 (C. elegans)

IDBP-603082

egl nine homolog 3 (C. elegans)

IDBP-597320

egl nine homolog 3 (C. elegans)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:33924231-34462774

Strand

Reverse strand

Band

q13.1

Transcripts

ENST00000250457	ENSP00000250457
ENST00000487915	ENSP00000451316
ENST00000464521
ENST00000553215	ENSP00000447470
ENST00000556785
ENST00000547327	ENSP00000446572
ENST00000550114
ENST00000551935
ENST00000548285
ENST00000546681
ENST00000557521

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	44 [view]
Protein-Protein	44 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0016491	oxidoreductase activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0031418	L-ascorbic acid binding
GO:0031545	peptidyl-proline 4-dioxygenase activity

Biological Process

GO:0001666	response to hypoxia
GO:0006915	apoptotic process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006974	cellular response to DNA damage stimulus
GO:0018126	protein hydroxylation
GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline
GO:0042127	regulation of cell proliferation
GO:0043523	regulation of neuron apoptotic process
GO:0055114	oxidation-reduction process
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0071456	cellular response to hypoxia

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000035105

View Gene Order

ENSBTAG00000008172

Not yet available

Pathways

NETPATH

REACTOME

REACT_120916

Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha pathway

REACT_120956

Cellular responses to stress pathway

REACT_120815

Regulation of Hypoxia-inducible Factor (HIF) by oxygen pathway

REACT_121311

Cellular response to hypoxia pathway

KEGG

hsa05211

Renal cell carcinoma pathway

hsa05200

Pathways in cancer pathway

INOH

PID NCI

hif1_tfpathway

HIF-1-alpha transcription factor network

Cross-References

SwissProt

TrEMBL

F8VR39

UniProt Splice Variant

Entrez Gene

112399

UniGene

Hs.135507 Hs.597964 Hs.664985 Hs.674838

RefSeq

NM_022073

HUGO

HGNC:14661

OMIM

606426

CCDS

CCDS9646

HPRD

06972

IMGT

EMBL

AL162191 AL356806 AL358274 AL358340

GenPept

RNA Seq Atlas

102724945 112399