Version 5.4
Homo sapiens Gene: PITX1
Summary
InnateDB Gene IDBG-45420.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PITX1
Gene Name paired-like homeodomain 1
Synonyms BFT; CCF; LBNBG; POTX; PTX1
Species Homo sapiens
Ensembl Gene ENSG00000069011
Encoded Proteins
IDBP-45422
paired-like homeodomain 1
IDBP-474038
paired-like homeodomain 1
IDBP-587560
paired-like homeodomain 1
IDBP-475141
paired-like homeodomain 1
IDBP-474418
paired-like homeodomain 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Members of this family are involved in organ development and left-right asymmetry. This protein acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:135027735-135034813
Strand Reverse strand
Band q31.1
Transcripts
ENST00000265340 ENSP00000265340
ENST00000506438 ENSP00000427542
ENST00000503586 ENSP00000451199
ENST00000504936
ENST00000507253 ENSP00000422908
ENST00000502676 ENSP00000423624
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 27 [view]
Protein-Protein 25 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001190 RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0001501 skeletal system development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0009653 anatomical structure morphogenesis
GO:0014707 branchiomeric skeletal muscle development
GO:0021983 pituitary gland development
GO:0035116 embryonic hindlimb morphogenesis
GO:0035137 hindlimb morphogenesis
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048625 myoblast fate commitment
GO:0051216 cartilage development
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005730 nucleolus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021506
View Gene Order
ENSBTAG00000004602
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 5307
UniGene Hs.84136
RefSeq NM_002653
HUGO HGNC:9004
OMIM 602149
CCDS CCDS4182
HPRD 03688
IMGT
EMBL
GenPept
RNA Seq Atlas 5307

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca