InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: H2AFY

Summary

InnateDB Gene

IDBG-45483.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

H2AFY

Gene Name

H2A histone family, member Y

Synonyms

H2A.y; H2A/y; H2AF12M; H2AFJ; MACROH2A1.1; macroH2A1.2; mH2A1

Species

Homo sapiens

Ensembl Gene

ENSG00000113648

Encoded Proteins

IDBP-45485

H2A histone family, member Y

IDBP-45487

H2A histone family, member Y

IDBP-377143

H2A histone family, member Y

IDBP-479110

H2A histone family, member Y

IDBP-479192

H2A histone family, member Y

IDBP-484647

H2A histone family, member Y

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and participates in stable X chromosome inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:135333900-135399914

Strand

Reverse strand

Band

q31.1

Transcripts

ENST00000304332	ENSP00000302572
ENST00000312469	ENSP00000310169
ENST00000360597
ENST00000423969	ENSP00000415121
ENST00000451949
ENST00000511689	ENSP00000423563
ENST00000512507
ENST00000511494
ENST00000506671	ENSP00000423718
ENST00000510038	ENSP00000424971
ENST00000505827
ENST00000513268
ENST00000507868
ENST00000508785
ENST00000513210
ENST00000504197
ENST00000508120
ENST00000506532
ENST00000506218
ENST00000508962

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 56 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	56 [view]
Protein-Protein	48 [view]
Protein-DNA	8 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000182	rDNA binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0010385	double-stranded methylated DNA binding
GO:0019901	protein kinase binding
GO:0030291	protein serine/threonine kinase inhibitor activity
GO:0031490	chromatin DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006334	nucleosome assembly
GO:0007549	dosage compensation
GO:0016568	chromatin modification
GO:0033128	negative regulation of histone phosphorylation
GO:0045814	negative regulation of gene expression, epigenetic
GO:0071169	establishment of protein localization to chromatin
GO:0071901	negative regulation of protein serine/threonine kinase activity
GO:1901837	negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter
GO:1902750	negative regulation of cell cycle G2/M phase transition

Cellular Component

GO:0000786	nucleosome
GO:0000790	nuclear chromatin
GO:0000793	condensed chromosome
GO:0001739	sex chromatin
GO:0001740	Barr body
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0035098	ESC/E(Z) complex
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000015937

View Gene Order

ENSBTAG00000016105

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa05322

Systemic lupus erythematosus pathway

INOH

PID NCI

atf2_pathway

ATF-2 transcription factor network

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.420272 Hs.610120 Hs.618942 Hs.666474 Hs.735401 Hs.737970

RefSeq

NM_001040158 NM_004893 NM_138609 NM_138610 XM_005272132

HUGO

OMIM

CCDS

CCDS4183 CCDS4184 CCDS4185

HPRD

13624

IMGT

EMBL

GenPept

RNA Seq Atlas