InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RPL19

Summary

InnateDB Gene

IDBG-45490.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RPL19

Gene Name

ribosomal protein L19

Synonyms

L19

Species

Homo sapiens

Ensembl Gene

ENSG00000108298

Encoded Proteins

IDBP-45492

ribosomal protein L19

IDBP-760370

IDBP-758924

IDBP-757740

IDBP-761072

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21860608

RPL19 inhibits IRF3 activation and CXCL10 production to facilitate viral multiplication in cells that express TLR3 in endosomes, and RPL19 inhibits viral multiplication in cells bearing TLR3 on their cell membrane.

InnateDB Annotation from Orthologs

Summary

PMID 21860608

[Mus musculus] Rpl19 inhibits Irf3 activation and Cxcl10 production to facilitate viral multiplication in cells that express Tlr3 in endosomes, and Rpl19 inhibits viral multiplication in cells bearing Tlr3 on their cell membrane. (Demonstrated in human)

Entrez Gene

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L19E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:39200283-39204727

Strand

Forward strand

Band

q12

Transcripts

ENST00000225430	ENSP00000225430
ENST00000580333
ENST00000579374	ENSP00000463985
ENST00000577741
ENST00000579260	ENSP00000464538
ENST00000585199	ENSP00000463329
ENST00000577759
ENST00000582193	ENSP00000462938

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 134 experimentally validated interaction(s) in this database.

Experimentally validated
Total	134 [view]
Protein-Protein	132 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0006412	translation
GO:0006413	translational initiation
GO:0006414	translational elongation
GO:0006415	translational termination
GO:0006614	SRP-dependent cotranslational protein targeting to membrane
GO:0010467	gene expression
GO:0016032	viral process
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0019058	viral life cycle
GO:0019083	viral transcription
GO:0044267	cellular protein metabolic process
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005622	intracellular
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0016020	membrane
GO:0022625	cytosolic large ribosomal subunit