Homo sapiens Gene: RPL19
Summary
InnateDB Gene IDBG-45490.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RPL19
Gene Name ribosomal protein L19
Synonyms L19;
Species Homo sapiens
Ensembl Gene ENSG00000108298
Encoded Proteins
ribosomal protein L19
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
RPL19 inhibits IRF3 activation and CXCL10 production to facilitate viral multiplication in cells that express TLR3 in endosomes, and RPL19 inhibits viral multiplication in cells bearing TLR3 on their cell membrane.
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Rpl19 inhibits Irf3 activation and Cxcl10 production to facilitate viral multiplication in cells that express Tlr3 in endosomes, and Rpl19 inhibits viral multiplication in cells bearing Tlr3 on their cell membrane. (Demonstrated in human)
Entrez Gene
Summary Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L19E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:39200283-39204727
Strand Forward strand
Band q12
Transcripts
ENST00000225430 ENSP00000225430
ENST00000580333
ENST00000579374 ENSP00000463985
ENST00000577741
ENST00000579260 ENSP00000464538
ENST00000585199 ENSP00000463329
ENST00000577759
ENST00000582193 ENSP00000462938
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 134 experimentally validated interaction(s) in this database.
Experimentally validated
Total 134 [view]
Protein-Protein 132 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0006412 translation
GO:0006413 translational initiation
GO:0006414 translational elongation
GO:0006415 translational termination
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
GO:0010467 gene expression
GO:0016032 viral process
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0019058 viral life cycle
GO:0019083 viral transcription
GO:0044267 cellular protein metabolic process
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005622 intracellular
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0016020 membrane
GO:0022625 cytosolic large ribosomal subunit
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Eukaryotic Translation Initiation pathway
Influenza Infection pathway
SRP-dependent cotranslational protein targeting to membrane pathway
Nonsense-Mediated Decay (NMD) pathway
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) pathway
Formation of a pool of free 40S subunits pathway
Influenza Viral RNA Transcription and Replication pathway
Translation pathway
Eukaryotic Translation Termination pathway
Metabolism of proteins pathway
Cap-dependent Translation Initiation pathway
Eukaryotic Translation Elongation pathway
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) pathway
Influenza Life Cycle pathway
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
Viral mRNA Translation pathway
Peptide chain elongation pathway
L13a-mediated translational silencing of Ceruloplasmin expression pathway
Gene Expression pathway
Disease pathway
KEGG
Ribosome pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.720729 Hs.731642
RefSeq NM_000981 XM_005257564
HUGO
OMIM
CCDS CCDS42312
HPRD 01594
IMGT
EMBL
GenPept
RNA Seq Atlas