Homo sapiens Gene: NDUFV3
Summary
InnateDB Gene IDBG-4553.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NDUFV3
Gene Name NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa
Synonyms CI-10k; CI-9KD;
Species Homo sapiens
Ensembl Gene ENSG00000160194
Encoded Proteins
NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa
NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is one of at least forty-one subunits that make up the NADH-ubiquinone oxidoreductase complex. This complex is part of the mitochondrial respiratory chain and serves to catalyze the rotenone-sensitive oxidation of NADH and the reduction of ubiquinone. The encoded protein is one of three proteins found in the flavoprotein fraction of the complex. The specific function of the encoded protein is unknown. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 21:42879644-42913304
Strand Forward strand
Band q22.3
Transcripts
ENST00000354250 ENSP00000346196
ENST00000340344 ENSP00000342895
ENST00000460259
ENST00000460740
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008137 NADH dehydrogenase (ubiquinone) activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006120 mitochondrial electron transport, NADH to ubiquinone
GO:0022904 respiratory electron transport chain
GO:0044237 cellular metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005747 mitochondrial respiratory chain complex I
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. pathway
The citric acid (TCA) cycle and respiratory electron transport pathway
Metabolism pathway
Respiratory electron transport pathway
KEGG
Oxidative phosphorylation pathway
Alzheimer's disease pathway
Parkinson's disease pathway
Huntington's disease pathway
INOH
PID BIOCARTA
PID NCI
Validated nuclear estrogen receptor alpha network
FOXA1 transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.473937
RefSeq NM_001001503 NM_021075
HUGO
OMIM
CCDS CCDS33572 CCDS33573
HPRD 03716
IMGT
EMBL
GenPept
RNA Seq Atlas