Version 5.4
Homo sapiens Gene: AGA
Summary
InnateDB Gene IDBG-45569.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AGA
Gene Name aspartylglucosaminidase
Synonyms AGU; ASRG; GA
Species Homo sapiens
Ensembl Gene ENSG00000038002
Encoded Proteins
IDBP-45571
aspartylglucosaminidase
IDBP-480807
aspartylglucosaminidase
IDBP-484314
aspartylglucosaminidase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Aspartylglucosaminidase is involved in the catabolism of N-linked oligosaccharides of glycoproteins. It cleaves asparagine from N-acetylglucosamines as one of the final steps in the lysosomal breakdown of glycoproteins. The lysosomal storage disease aspartylglycosaminuria is caused by a deficiency in the AGA enzyme. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Jan 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:177430770-177442503
Strand Reverse strand
Band q34.3
Transcripts
ENST00000264595 ENSP00000264595
ENST00000502310 ENSP00000423798
ENST00000506853
ENST00000510635 ENSP00000421471
ENST00000510955
ENST00000511231
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003948 N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity
GO:0008233 peptidase activity
GO:0016787 hydrolase activity
GO:0043621 protein self-association
Biological Process
GO:0006508 proteolysis
GO:0006517 protein deglycosylation
GO:0008152 metabolic process
GO:0051604 protein maturation
Cellular Component
GO:0005764 lysosome
GO:0005783 endoplasmic reticulum
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031521
View Gene Order
ENSBTAG00000017085
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00511
Other glycan degradation pathway
hsa04142
Lysosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.207776 Hs.605070
RefSeq NM_000027 NM_001171988 XM_006714123
HUGO
OMIM
CCDS CCDS3829
HPRD 01949
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca