Version 5.4
Homo sapiens Gene: FBXO31
Summary
InnateDB Gene IDBG-45593.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FBXO31
Gene Name F-box protein 31
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000103264
Encoded Proteins
IDBP-45595
F-box protein 31
IDBP-748273
IDBP-749719
IDBP-810186
F-box protein 31
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Members of the F-box protein family, such as FBXO31, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:87326987-87392142
Strand Reverse strand
Band q24.2
Transcripts
ENST00000311635 ENSP00000310841
ENST00000565593 ENSP00000455772
ENST00000563956
ENST00000561664
ENST00000563113 ENSP00000457578
ENST00000569412
ENST00000567622
ENST00000618298 ENSP00000479703
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 11 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0030332 cyclin binding
Biological Process
GO:0006974 cellular response to DNA damage stimulus
GO:0008054 cyclin catabolic process
GO:0016567 protein ubiquitination
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031571 mitotic G1 DNA damage checkpoint
Cellular Component
GO:0019005 SCF ubiquitin ligase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000052934
View Gene Order
ENSBTAG00000002226
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.666570
RefSeq NM_001282683 NM_024735
HUGO
OMIM
CCDS CCDS32501 CCDS73922
HPRD 10954
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca