Version 5.4
Homo sapiens Gene: SNX6
Summary
InnateDB Gene IDBG-4564.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SNX6
Gene Name sorting nexin 6
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000129515
Encoded Proteins
IDBP-4566
sorting nexin 6
IDBP-237300
sorting nexin 6
IDBP-589600
sorting nexin 6
IDBP-595670
sorting nexin 6
IDBP-599846
sorting nexin 6
IDBP-583118
sorting nexin 6
IDBP-601848
sorting nexin 6
IDBP-584554
sorting nexin 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associates with the long isoform of the leptin receptor, the transforming growth factor-beta family of receptor serine-threonine kinases, and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor. This protein may form oligomeric complexes with family member proteins through interactions of both the PX domain and the coiled coil regions of the molecules. Translocation of this protein from the cytoplasm to the nucleus occurs after binding to proviral integration site 1 protein. This gene results in two transcripts encoding two distinct isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:34561094-34630183
Strand Reverse strand
Band q13.1
Transcripts
ENST00000362031 ENSP00000355217
ENST00000396526 ENSP00000379779
ENST00000556162 ENSP00000452231
ENST00000555416 ENSP00000452082
ENST00000555541
ENST00000556712 ENSP00000451415
ENST00000557265 ENSP00000452577
ENST00000557341 ENSP00000450863
ENST00000556303
ENST00000555648 ENSP00000452520
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 50 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 50 [view]
Protein-Protein 49 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0034713 type I transforming growth factor beta receptor binding
GO:0035091 phosphatidylinositol binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006886 intracellular protein transport
GO:0007175 negative regulation of epidermal growth factor-activated receptor activity
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0042147 retrograde transport, endosome to Golgi
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0030659 cytoplasmic vesicle membrane
GO:0031901 early endosome membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000005656
View Gene Order
ENSBTAG00000012873
Not yet available
Pathways
NETPATH
NetPath_7
TGF_beta_Receptor pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.276523 Hs.356647 Hs.629592 Hs.720717
RefSeq NM_021249 NM_152233 XM_006720224
HUGO
OMIM
CCDS CCDS41942 CCDS9648
HPRD 12086
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca