Version 5.4
Homo sapiens Gene: PKNOX1
Summary
InnateDB Gene IDBG-4584.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PKNOX1
Gene Name PBX/knotted 1 homeobox 1
Synonyms pkonx1c; PREP1
Species Homo sapiens
Ensembl Gene ENSG00000160199
Encoded Proteins
IDBP-4586
PBX/knotted 1 homeobox 1
IDBP-368973
PBX/knotted 1 homeobox 1
IDBP-585241
PBX/knotted 1 homeobox 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 21:42974510-43033931
Strand Forward strand
Band q22.3
Transcripts
ENST00000291547 ENSP00000291547
ENST00000456957
ENST00000418336
ENST00000432907 ENSP00000402243
ENST00000480179
ENST00000474336
ENST00000560448 ENSP00000453486
ENST00000557820
ENST00000558955
ENST00000607049
ENST00000607150
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 14 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0001525 angiogenesis
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0030097 hemopoiesis
GO:0030217 T cell differentiation
GO:0030218 erythrocyte differentiation
GO:0043010 camera-type eye development
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000006705
View Gene Order
ENSBTAG00000014153
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.431043 Hs.593043 Hs.621027
RefSeq NM_001286258 NM_004571
HUGO
OMIM
CCDS CCDS13692 CCDS68211
HPRD 03653
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca