InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: EPHA3

Summary

InnateDB Gene

IDBG-45928.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EPHA3

Gene Name

EPH receptor A3

Synonyms

EK4; ETK; ETK1; HEK; HEK4; TYRO4

Species

Homo sapiens

Ensembl Gene

ENSG00000044524

Encoded Proteins

IDBP-45930

EPH receptor A3

IDBP-381514

EPH receptor A3

IDBP-478678

EPH receptor A3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:89107524-89482134

Strand

Forward strand

Band

p11.1

Transcripts

ENST00000336596	ENSP00000337451
ENST00000452448	ENSP00000399926
ENST00000494014	ENSP00000419190

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	23 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005003	ephrin receptor activity
GO:0005004	GPI-linked ephrin receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0007155	cell adhesion
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0010717	regulation of epithelial to mesenchymal transition
GO:0010976	positive regulation of neuron projection development
GO:0016477	cell migration
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0032319	regulation of Rho GTPase activity
GO:0032956	regulation of actin cytoskeleton organization
GO:0048013	ephrin receptor signaling pathway
GO:0051893	regulation of focal adhesion assembly
GO:0070507	regulation of microtubule cytoskeleton organization
GO:0071300	cellular response to retinoic acid
GO:0097155	fasciculation of sensory neuron axon
GO:0097156	fasciculation of motor neuron axon

Cellular Component

GO:0005576	extracellular region
GO:0005769	early endosome
GO:0005887	integral component of plasma membrane

Orthologs

Species

Mus musculus

Gene ID

Gene Order

ENSMUSG00000052504

View Gene Order

Pathways

NETPATH

NetPath_11

TCR pathway

REACTOME

REACT_111045

Developmental Biology pathway

REACT_18266

Axon guidance pathway

REACT_228063

EPHA-mediated growth cone collapse pathway

REACT_228189

EPH-ephrin mediated repulsion of cells pathway

REACT_228170

EPH-Ephrin signaling pathway

KEGG

hsa04360

Axon guidance pathway

INOH

PID NCI

epha_fwdpathway

EPHA forward signaling

Cross-References

SwissProt

TrEMBL

C9JXA2

UniProt Splice Variant

Entrez Gene

2042

UniGene

Hs.123642

RefSeq

XM_005264716 NM_005233 NM_182644 XM_005264715

HUGO

HGNC:3387

OMIM

179611

CCDS

CCDS2922 CCDS46875

HPRD

01555

IMGT

EMBL

AC107028 AC109129 AC138973

GenPept

RNA Seq Atlas

2042