Version 5.4
Homo sapiens Gene: HCST
Summary
InnateDB Gene IDBG-45994.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HCST
Gene Name hematopoietic cell signal transducer
Synonyms DAP10; KAP10; PIK3AP
Species Homo sapiens
Ensembl Gene ENSG00000126264
Encoded Proteins
IDBP-45996
hematopoietic cell signal transducer
IDBP-378496
hematopoietic cell signal transducer
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a transmembrane signaling adaptor that contains a YxxM motif in its cytoplasmic domain. The encoded protein may form part of the immune recognition receptor complex with the C-type lectin-like receptor NKG2D. As part of this receptor complex, this protein may activate phosphatidylinositol 3-kinase dependent signaling pathways through its intracytoplasmic YxxM motif. This receptor complex may have a role in cell survival and proliferation by activation of NK and T cell responses. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:35902480-35904377
Strand Forward strand
Band q13.12
Transcripts
ENST00000246551 ENSP00000246551
ENST00000437550 ENSP00000400516
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0043548 phosphatidylinositol 3-kinase binding
Biological Process
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0050776 regulation of immune response
Cellular Component
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000064109
View Gene Order
ENSBTAG00000007336
Not yet available
Pathways
NETPATH
REACTOME
REACT_11152
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
KEGG
hsa04650
Natural killer cell mediated cytotoxicity pathway
INOH
PID NCI
Cross-References
SwissProt Q9UBK5
TrEMBL
UniProt Splice Variant
Entrez Gene 10870
UniGene
RefSeq NM_001007469 NM_014266
HUGO HGNC:16977
OMIM 604089
CCDS CCDS46057 CCDS32998
HPRD 04971
IMGT
EMBL AF072844 AF072845 AF122904 AF172929 AF285447 AL050163 AY359058 BC035931 BC046348 BC065224
GenPept AAD46986 AAD46987 AAD47911 AAD50293 AAG29425 AAH35931 AAH46348 AAH65224 AAQ89417 CAB43303
RNA Seq Atlas 10870

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca