Version 5.4
Homo sapiens Gene: ZFPM1
Summary
InnateDB Gene IDBG-46137.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZFPM1
Gene Name zinc finger protein, multitype 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000179588
Encoded Proteins
IDBP-46139
zinc finger protein, multitype 1
IDBP-811089
zinc finger protein, FOG family member 1
IDBP-811087
zinc finger protein, FOG family member 1
IDBP-811086
zinc finger protein, FOG family member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21971825
ZFPM1 inhibits the transcription of hepcidin antimicrobial peptide by suppressing the GATA4 and GATA6 transcription factors.
InnateDB Annotation from Orthologs
Summary
PMID 21971825
[Mus musculus] Zfpm1 inhibits the transcription of hepcidin antimicrobial peptide by suppressing the GATA4 and GATA6 transcription factors. (Demonstrated in human)
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 16:88453317-88537016
Strand Forward strand
Band q24.2
Transcripts
ENST00000319555 ENSP00000326630
ENST00000562437 ENSP00000480412
ENST00000562417
ENST00000563351 ENSP00000484216
ENST00000569086 ENSP00000482796
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 10 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001085 RNA polymerase II transcription factor binding
GO:0001102 RNA polymerase II activating transcription factor binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0046872 metal ion binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0002295 T-helper cell lineage commitment
GO:0003151 outflow tract morphogenesis
GO:0003181 atrioventricular valve morphogenesis
GO:0003192 mitral valve formation
GO:0003195 tricuspid valve formation
GO:0006351 transcription, DNA-templated
GO:0007507 heart development
GO:0007596 blood coagulation
GO:0010724 regulation of definitive erythrocyte differentiation
GO:0030218 erythrocyte differentiation
GO:0030219 megakaryocyte differentiation
GO:0030220 platelet formation
GO:0030851 granulocyte differentiation
GO:0032091 negative regulation of protein binding
GO:0032642 regulation of chemokine production
GO:0035162 embryonic hemopoiesis
GO:0035855 megakaryocyte development
GO:0045078 positive regulation of interferon-gamma biosynthetic process
GO:0045087 innate immune response (InnateDB)
GO:0045403 negative regulation of interleukin-4 biosynthetic process
GO:0045599 negative regulation of fat cell differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048872 homeostasis of number of cells
GO:0055008 cardiac muscle tissue morphogenesis
GO:0060318 definitive erythrocyte differentiation
GO:0060319 primitive erythrocyte differentiation
GO:0060377 negative regulation of mast cell differentiation
GO:0060412 ventricular septum morphogenesis
GO:0060413 atrial septum morphogenesis
GO:0071733 transcriptional activation by promoter-enhancer looping
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
GO:0017053 transcriptional repressor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000049577
View Gene Order
ENSBTAG00000015766
Not yet available
Pathways
NETPATH
REACTOME
REACT_24970
Factors involved in megakaryocyte development and platelet production pathway
REACT_604
Hemostasis pathway
KEGG
INOH
PID NCI
hdac_classi_pathway
Signaling events mediated by HDAC Class I
cmyb_pathway
C-MYB transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.632218
RefSeq NM_153813
HUGO
OMIM
CCDS CCDS32502
HPRD 11800
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca