InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CCT2

Summary

InnateDB Gene

IDBG-47181.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCT2

Gene Name

chaperonin containing TCP1, subunit 2 (beta)

Synonyms

99D8.1; CCT-beta; CCTB; HEL-S-100n; PRO1633; TCP-1-beta

Species

Homo sapiens

Ensembl Gene

ENSG00000166226

Encoded Proteins

IDBP-47183

chaperonin containing TCP1, subunit 2 (beta)

IDBP-601064

chaperonin containing TCP1, subunit 2 (beta)

IDBP-600615

chaperonin containing TCP1, subunit 2 (beta)

IDBP-599396

chaperonin containing TCP1, subunit 2 (beta)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:69585334-69601570

Strand

Forward strand

Band

q15

Transcripts

ENST00000299300	ENSP00000299300
ENST00000546859
ENST00000549933
ENST00000550455
ENST00000550638
ENST00000551620
ENST00000551899
ENST00000544368	ENSP00000441847
ENST00000550010	ENSP00000450153
ENST00000543146	ENSP00000445471
ENST00000548787
ENST00000546850
ENST00000553169
ENST00000550653

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 140 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	140 [view]
Protein-Protein	140 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0051082	unfolded protein binding

Biological Process

GO:0006457	protein folding
GO:0007339	binding of sperm to zona pellucida
GO:0044267	cellular protein metabolic process
GO:0051084	'de novo' posttranslational protein folding
GO:0051131	chaperone-mediated protein complex assembly

Cellular Component

GO:0002199	zona pellucida receptor complex
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005832	chaperonin-containing T-complex
GO:0005874	microtubule
GO:0044297	cell body
GO:0070062	extracellular vesicular exosome