Homo sapiens Gene: CCT2
Summary
InnateDB Gene IDBG-47181.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCT2
Gene Name chaperonin containing TCP1, subunit 2 (beta)
Synonyms 99D8.1; CCT-beta; CCTB; HEL-S-100n; PRO1633; TCP-1-beta;
Species Homo sapiens
Ensembl Gene ENSG00000166226
Encoded Proteins
chaperonin containing TCP1, subunit 2 (beta)
chaperonin containing TCP1, subunit 2 (beta)
chaperonin containing TCP1, subunit 2 (beta)
chaperonin containing TCP1, subunit 2 (beta)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:69585334-69601570
Strand Forward strand
Band q15
Transcripts
ENST00000299300 ENSP00000299300
ENST00000546859
ENST00000549933
ENST00000550455
ENST00000550638
ENST00000551620
ENST00000551899
ENST00000544368 ENSP00000441847
ENST00000550010 ENSP00000450153
ENST00000543146 ENSP00000445471
ENST00000548787
ENST00000546850
ENST00000553169
ENST00000550653
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 140 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 140 [view]
Protein-Protein 140 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0051082 unfolded protein binding
Biological Process
GO:0006457 protein folding
GO:0007339 binding of sperm to zona pellucida
GO:0044267 cellular protein metabolic process
GO:0051084 'de novo' posttranslational protein folding
GO:0051131 chaperone-mediated protein complex assembly
Cellular Component
GO:0002199 zona pellucida receptor complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005832 chaperonin-containing T-complex
GO:0005874 microtubule
GO:0044297 cell body
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Formation of tubulin folding intermediates by CCT/TriC pathway
Protein folding pathway
Folding of actin by CCT/TriC pathway
Chaperonin-mediated protein folding pathway
Metabolism of proteins pathway
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding pathway
Association of TriC/CCT with target proteins during biosynthesis pathway
Prefoldin mediated transfer of substrate to CCT/TriC pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.189772
RefSeq NM_001198842 NM_006431
HUGO
OMIM
CCDS CCDS55843 CCDS8991
HPRD 06895
IMGT
EMBL
GenPept
RNA Seq Atlas