Homo sapiens Gene: RPL13
Summary
InnateDB Gene IDBG-47646.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RPL13
Gene Name ribosomal protein L13
Synonyms BBC1; D16S444E; D16S44E; L13;
Species Homo sapiens
Ensembl Gene ENSG00000167526
Encoded Proteins
ribosomal protein L13
ribosomal protein L13
ribosomal protein L13
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L13E family of ribosomal proteins. It is located in the cytoplasm. This gene is expressed at significantly higher levels in benign breast lesions than in breast carcinomas. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:89560657-89566828
Strand Forward strand
Band q24.3
Transcripts
ENST00000311528 ENSP00000307889
ENST00000399461
ENST00000393099 ENSP00000376811
ENST00000452368 ENSP00000438959
ENST00000491523
ENST00000484610
ENST00000487034
ENST00000467736 ENSP00000464612
ENST00000472354 ENSP00000462380
ENST00000567815 ENSP00000455009
ENST00000563270 ENSP00000457686
ENST00000565571
ENST00000563749
ENST00000570149
ENST00000562879 ENSP00000457174
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 131 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 131 [view]
Protein-Protein 129 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0006412 translation
GO:0006413 translational initiation
GO:0006414 translational elongation
GO:0006415 translational termination
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
GO:0010467 gene expression
GO:0016032 viral process
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0019058 viral life cycle
GO:0019083 viral transcription
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0016020 membrane
GO:0022625 cytosolic large ribosomal subunit
GO:0022626 cytosolic ribosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Eukaryotic Translation Initiation pathway
Influenza Infection pathway
SRP-dependent cotranslational protein targeting to membrane pathway
Nonsense-Mediated Decay (NMD) pathway
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) pathway
Formation of a pool of free 40S subunits pathway
Influenza Viral RNA Transcription and Replication pathway
Translation pathway
Eukaryotic Translation Termination pathway
Metabolism of proteins pathway
Cap-dependent Translation Initiation pathway
Eukaryotic Translation Elongation pathway
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) pathway
Influenza Life Cycle pathway
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
Viral mRNA Translation pathway
Peptide chain elongation pathway
L13a-mediated translational silencing of Ceruloplasmin expression pathway
Gene Expression pathway
Disease pathway
KEGG
Ribosome pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P26373
TrEMBL A8K4C8 H3BTH3 H3BUK8 J3QSB4 O60250
UniProt Splice Variant
Entrez Gene 6137
UniGene Hs.410817
RefSeq NM_000977 NM_001243130 NM_001243131 NM_033251
HUGO HGNC:10303
OMIM 113703
CCDS CCDS10979 CCDS58492
HPRD
IMGT
EMBL AB007172 AB062392 AC092123 AK127579 AK290893 AK297198 BC004954 BC007345 BC007563 BC007805 BC010994 BC013078 BC014167 BC020804 BC027463 BC063378 BC093063 BC106058 CH471184 X64707
GenPept AAH04954 AAH07345 AAH07563 AAH07805 AAH10994 AAH13078 AAH14167 AAH20804 AAH27463 AAH63378 AAH93063 AAI06059 BAA25832 BAB93479 BAF83582 BAG54527 BAG59685 CAA45963 EAW66724 EAW66725
RNA Seq Atlas 606500 6137