Version 5.4
Homo sapiens Gene: PTPRB
Summary
InnateDB Gene IDBG-47655.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTPRB
Gene Name protein tyrosine phosphatase, receptor type, B
Synonyms HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP
Species Homo sapiens
Ensembl Gene ENSG00000127329
Encoded Proteins
IDBP-47657
protein tyrosine phosphatase, receptor type, B
IDBP-47659
protein tyrosine phosphatase, receptor type, B
IDBP-380039
protein tyrosine phosphatase, receptor type, B
IDBP-598372
protein tyrosine phosphatase, receptor type, B
IDBP-597978
protein tyrosine phosphatase, receptor type, B
IDBP-603430
protein tyrosine phosphatase, receptor type, B
IDBP-588020
protein tyrosine phosphatase, receptor type, B
IDBP-586938
protein tyrosine phosphatase, receptor type, B
IDBP-586467
protein tyrosine phosphatase, receptor type, B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and one intracytoplasmic catalytic domain, thus belongs to receptor type PTP. The extracellular region of this PTP is composed of multiple fibronectin type_III repeats, which was shown to interact with neuronal receptor and cell adhesion molecules, such as contactin and tenascin C. This protein was also found to interact with sodium channels, and thus may regulate sodium channels by altering tyrosine phosphorylation status. The functions of the interaction partners of this protein implicate the roles of this PTP in cell adhesion, neurite growth, and neuronal differentiation. Alternate transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:70515866-70637440
Strand Reverse strand
Band q15
Transcripts
ENST00000261266 ENSP00000261266
ENST00000334414 ENSP00000334928
ENST00000451516 ENSP00000393028
ENST00000550358 ENSP00000448058
ENST00000538708 ENSP00000438927
ENST00000550857 ENSP00000447302
ENST00000549400
ENST00000551525 ENSP00000448349
ENST00000548122 ENSP00000446982
ENST00000538174
ENST00000552253
ENST00000547715 ENSP00000446934
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 39 [view]
Protein-Protein 39 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0016791 phosphatase activity
Biological Process
GO:0001525 angiogenesis
GO:0006470 protein dephosphorylation
GO:0006796 phosphate-containing compound metabolic process
GO:0016311 dephosphorylation
GO:0035335 peptidyl-tyrosine dephosphorylation
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0043235 receptor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020154
View Gene Order
ENSBTAG00000015296
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04520
Adherens junction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.434375
RefSeq NM_001109754 NM_001206971 NM_001206972 NM_002837 XM_006719528 XM_006719529 XM_006719530
HUGO
OMIM
CCDS CCDS44943 CCDS44944 CCDS55845 CCDS55846
HPRD 01474
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca