Homo sapiens Gene: CD226
Summary
InnateDB Gene IDBG-4779.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD226
Gene Name CD226 molecule
Synonyms DNAM-1; DNAM1; PTA1; TLiSA1;
Species Homo sapiens
Ensembl Gene ENSG00000150637
Encoded Proteins
CD226 molecule
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. The protein mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a role in megakaryocytic cell maturation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:69831158-69961803
Strand Reverse strand
Band q22.2
Transcripts
ENST00000280200 ENSP00000280200
ENST00000583955 ENSP00000464334
ENST00000580335 ENSP00000463335
ENST00000578928 ENSP00000463152
ENST00000579496 ENSP00000463927
ENST00000577287 ENSP00000462453
ENST00000581982 ENSP00000464084
ENST00000582621 ENSP00000461947
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0050839 cell adhesion molecule binding
Biological Process
GO:0001816 cytokine production
GO:0002860 positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
GO:0002891 positive regulation of immunoglobulin mediated immune response
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0008037 cell recognition
GO:0033005 positive regulation of mast cell activation
GO:0045954 positive regulation of natural killer cell mediated cytotoxicity
GO:0050776 regulation of immune response
GO:0060369 positive regulation of Fc receptor mediated stimulatory signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0045121 membrane raft
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
Adaptive Immune System pathway
Immune System pathway
KEGG
Cell adhesion molecules (CAMs) pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL J3QKM7 J3QR77
UniProt Splice Variant
Entrez Gene 10666
UniGene Hs.605048 Hs.660130
RefSeq NM_006566 XM_005266643 XM_006722374
HUGO HGNC:16961
OMIM 605397
CCDS CCDS11997
HPRD 09252
IMGT
EMBL AC011930 AC090231 AC091137
GenPept
RNA Seq Atlas 10666