Version 5.4
Homo sapiens Gene: CD226
Summary
InnateDB Gene IDBG-4779.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD226
Gene Name CD226 molecule
Synonyms DNAM-1; DNAM1; PTA1; TLiSA1
Species Homo sapiens
Ensembl Gene ENSG00000150637
Encoded Proteins
IDBP-4781
CD226 molecule
IDBP-726546
IDBP-728082
IDBP-725684
IDBP-725693
IDBP-726776
IDBP-726996
IDBP-725965
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. The protein mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a role in megakaryocytic cell maturation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:69831158-69961803
Strand Reverse strand
Band q22.2
Transcripts
ENST00000280200 ENSP00000280200
ENST00000583955 ENSP00000464334
ENST00000580335 ENSP00000463335
ENST00000578928 ENSP00000463152
ENST00000579496 ENSP00000463927
ENST00000577287 ENSP00000462453
ENST00000581982 ENSP00000464084
ENST00000582621 ENSP00000461947
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0050839 cell adhesion molecule binding
Biological Process
GO:0001816 cytokine production
GO:0002860 positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
GO:0002891 positive regulation of immunoglobulin mediated immune response
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0008037 cell recognition
GO:0033005 positive regulation of mast cell activation
GO:0045954 positive regulation of natural killer cell mediated cytotoxicity
GO:0050776 regulation of immune response
GO:0060369 positive regulation of Fc receptor mediated stimulatory signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0045121 membrane raft
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000034028
View Gene Order
Pathways
NETPATH
REACTOME
REACT_11152
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.605048 Hs.660130
RefSeq NM_006566 XM_005266643 XM_006722374
HUGO
OMIM
CCDS CCDS11997
HPRD 09252
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca