InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: UBE2D2

Summary

InnateDB Gene

IDBG-47921.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBE2D2

Gene Name

ubiquitin-conjugating enzyme E2D 2

Synonyms

E2(17)KB2; PUBC1; UBC4; UBC4/5; UBCH4; UBCH5B

Species

Homo sapiens

Ensembl Gene

ENSG00000131508

Encoded Proteins

IDBP-47923

ubiquitin-conjugating enzyme E2D 2

IDBP-232331

ubiquitin-conjugating enzyme E2D 2

IDBP-232333

ubiquitin-conjugating enzyme E2D 2

IDBP-482459

ubiquitin-conjugating enzyme E2D 2

IDBP-476191

ubiquitin-conjugating enzyme E2D 2

IDBP-482134

ubiquitin-conjugating enzyme E2D 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. Two alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms. [provided by RefSeq, Jul 2008]
Regulated degradation of misfolded, damaged or short-lived proteins in eukaryotes occurs via the ubiquitin (Ub)-proteasome system (UPS). An integral part of the UPS system is the ubiquitination of target proteins and covalent linkage of Ub-containing proteins to form polymeric chains, marking them as targets for 26S proteasome-mediated degradation. Ubiquitination of proteins is mediated by a cascade of enzymes which includes E1 (ubiquitin activating), E2 (ubiquitin conjugating), and E3 (ubiquitin ligases) enzymes. This gene encodes a member of the E2 enzyme family. Substrates of this enzyme include the tumor suppressor protein p53 and peroxisomal biogenesis factor 5 (PEX5). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:139526431-139628433

Strand

Forward strand

Band

q31.2

Transcripts

ENST00000253815	ENSP00000253815
ENST00000398734	ENSP00000381718
ENST00000398733	ENSP00000381717
ENST00000511725	ENSP00000429613
ENST00000505007	ENSP00000426523
ENST00000510470
ENST00000505548	ENSP00000424941
ENST00000511691

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 239 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	239 [view]
Protein-Protein	239 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016881	acid-amino acid ligase activity

Biological Process

GO:0000209	protein polyubiquitination
GO:0002224	toll-like receptor signaling pathway
GO:0002756	MyD88-independent toll-like receptor signaling pathway
GO:0006464	cellular protein modification process
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0008152	metabolic process
GO:0016567	protein ubiquitination
GO:0034138	toll-like receptor 3 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0035666	TRIF-dependent toll-like receptor signaling pathway
GO:0045087	innate immune response
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0070936	protein K48-linked ubiquitination
GO:0071456	cellular response to hypoxia