Version 5.4
Homo sapiens Gene: ALCAM
Summary
InnateDB Gene IDBG-48383.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ALCAM
Gene Name activated leukocyte cell adhesion molecule
Synonyms CD166; MEMD
Species Homo sapiens
Ensembl Gene ENSG00000170017
Encoded Proteins
IDBP-48385
activated leukocyte cell adhesion molecule
IDBP-477057
activated leukocyte cell adhesion molecule
IDBP-477960
activated leukocyte cell adhesion molecule
IDBP-474935
activated leukocyte cell adhesion molecule
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes activated leukocyte cell adhesion molecule (ALCAM), also known as CD166 (cluster of differentiation 166), which is a member of a subfamily of immunoglobulin receptors with five immunoglobulin-like domains (VVC2C2C2) in the extracellular domain. This protein binds to T-cell differentiation antigene CD6, and is implicated in the processes of cell adhesion and migration. Multiple alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:105366909-105576900
Strand Forward strand
Band q13.11
Transcripts
ENST00000306107 ENSP00000305988
ENST00000470756
ENST00000472644 ENSP00000419236
ENST00000481337
ENST00000486979 ENSP00000418213
ENST00000460954
ENST00000465413 ENSP00000418937
ENST00000491388
ENST00000489178
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 7 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005515 protein binding
Biological Process
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0007411 axon guidance
GO:0008045 motor neuron axon guidance
Cellular Component
GO:0009897 external side of plasma membrane
GO:0016021 integral component of membrane
GO:0030424 axon
GO:0043025 neuronal cell body
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022636
View Gene Order
ENSBTAG00000000088
Not yet available
Pathways
NETPATH
REACTOME
REACT_22205
L1CAM interactions pathway
REACT_111045
Developmental Biology pathway
REACT_18266
Axon guidance pathway
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.591293 Hs.740441
RefSeq NM_001243280 NM_001243281 NM_001627
HUGO
OMIM
CCDS CCDS33810 CCDS58841
HPRD 03389
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca