Version 5.4
Homo sapiens Gene: TPP2
Summary
InnateDB Gene IDBG-48458.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TPP2
Gene Name tripeptidyl peptidase II
Synonyms TPP-2
Species Homo sapiens
Ensembl Gene ENSG00000134900
Encoded Proteins
IDBP-48460
tripeptidyl peptidase II
IDBP-48462
tripeptidyl peptidase II
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 25525876
TPPII controls the balance between intracellular amino acid availability, lysosome number, and glycolysis, which is vital for adaptive and innate immunity and neurodevelopmental health.
Entrez Gene
Summary This gene encodes a mammalian peptidase that, at neutral pH, removes tripeptides from the N terminus of longer peptides. The protein has a specialized function that is essential for some MHC class I antigen presentation. The protein is a high molecular mass serine exopeptidase; the amino acid sequence surrounding the serine residue at the active site is similar to the peptidases of the subtilisin class rather than the trypsin class. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:102597003-102679958
Strand Forward strand
Band q33.1
Transcripts
ENST00000376065 ENSP00000365233
ENST00000376052 ENSP00000365220
ENST00000490010
ENST00000496126
ENST00000493770
ENST00000490420
ENST00000466153
ENST00000482393
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 8 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004175 endopeptidase activity
GO:0004177 aminopeptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0008240 tripeptidyl-peptidase activity
GO:0042277 peptide binding
Biological Process
GO:0000209 protein polyubiquitination
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
GO:0006508 proteolysis
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000041763
View Gene Order
ENSBTAG00000020389
Not yet available
Pathways
NETPATH
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.432424 Hs.600959
RefSeq NM_003291 XM_005254072 XM_005254073
HUGO
OMIM
CCDS CCDS9502
HPRD 01834
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca