InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TGIF1

Summary

InnateDB Gene

IDBG-489.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TGIF1

Gene Name

TGFB-induced factor homeobox 1

Synonyms

HPE4; TGIF

Species

Homo sapiens

Ensembl Gene

ENSG00000177426

Encoded Proteins

IDBP-491

TGFB-induced factor homeobox 1

IDBP-495

TGFB-induced factor homeobox 1

IDBP-497

TGFB-induced factor homeobox 1

IDBP-228884

TGFB-induced factor homeobox 1

IDBP-292424

TGFB-induced factor homeobox 1

IDBP-292427

TGFB-induced factor homeobox 1

IDBP-292428

TGFB-induced factor homeobox 1

IDBP-596224

TGFB-induced factor homeobox 1

IDBP-603712

TGFB-induced factor homeobox 1

IDBP-590072

TGFB-induced factor homeobox 1

IDBP-592597

TGFB-induced factor homeobox 1

IDBP-594615

TGFB-induced factor homeobox 1

IDBP-593124

TGFB-induced factor homeobox 1

IDBP-600169

TGFB-induced factor homeobox 1

IDBP-600741

TGFB-induced factor homeobox 1

IDBP-583162

TGFB-induced factor homeobox 1

IDBP-594424

TGFB-induced factor homeobox 1

IDBP-596371

TGFB-induced factor homeobox 1

IDBP-586677

TGFB-induced factor homeobox 1

IDBP-726219

IDBP-809820

TGFB-induced factor homeobox 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and eight variants, encoding four distinct isoforms, are described. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and multiple splice variants encoding distinct isoforms are described. [provided by RefSeq, Jul 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:3411608-3459978

Strand

Forward strand

Band

p11.31

Transcripts

ENST00000345133	ENSP00000343969
ENST00000343820	ENSP00000339631
ENST00000330513	ENSP00000327959
ENST00000400167	ENSP00000383031
ENST00000407501	ENSP00000384133
ENST00000405385	ENSP00000384970
ENST00000401449	ENSP00000385206
ENST00000472042	ENSP00000449501
ENST00000552383	ENSP00000449287
ENST00000547233
ENST00000550958	ENSP00000449531
ENST00000548489	ENSP00000447747
ENST00000549780	ENSP00000448121
ENST00000549253	ENSP00000449973
ENST00000551557
ENST00000546979	ENSP00000448934
ENST00000551402	ENSP00000446944
ENST00000551541	ENSP00000450025
ENST00000549546	ENSP00000449580
ENST00000549468	ENSP00000449722
ENST00000551333	ENSP00000446838
ENST00000577543	ENSP00000462285
ENST00000618001	ENSP00000483499

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	32 [view]
Protein-Protein	31 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0070410	co-SMAD binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001843	neural tube closure
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007275	multicellular organismal development
GO:0007368	determination of left/right symmetry
GO:0008285	negative regulation of cell proliferation
GO:0009953	dorsal/ventral pattern formation
GO:0010467	gene expression
GO:0010470	regulation of gastrulation
GO:0010629	negative regulation of gene expression
GO:0038092	nodal signaling pathway
GO:0042493	response to drug
GO:0045666	positive regulation of neuron differentiation
GO:0048146	positive regulation of fibroblast proliferation
GO:0048387	negative regulation of retinoic acid receptor signaling pathway
GO:0060041	retina development in camera-type eye
GO:0071363	cellular response to growth factor stimulus