Homo sapiens Gene: FAN1
Summary
InnateDB Gene IDBG-4900.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FAN1
Gene Name FANCD2/FANCI-associated nuclease 1
Synonyms KIAA1018; KMIN; MTMR15;
Species Homo sapiens
Ensembl Gene ENSG00000198690
Encoded Proteins
FANCD2/FANCI-associated nuclease 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the myotubularin-related class 1 cysteine-based protein tyrosine phosphatases. The encoded protein may be catalytically inactive. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:30903852-30943108
Strand Forward strand
Band q13.3
Transcripts
ENST00000362065 ENSP00000354497
ENST00000561594 ENSP00000455983
ENST00000561607 ENSP00000454223
ENST00000562881
ENST00000565280 ENSP00000455573
ENST00000565466 ENSP00000454544
ENST00000562892 ENSP00000457680
ENST00000568145
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
Experimentally validated
Total 21 [view]
Protein-Protein 21 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0004528 phosphodiesterase I activity
GO:0005515 protein binding
GO:0008409 5'-3' exonuclease activity
GO:0016788 hydrolase activity, acting on ester bonds
GO:0017108 5'-flap endonuclease activity
GO:0043130 ubiquitin binding
Biological Process
GO:0000724 double-strand break repair via homologous recombination
GO:0000737 DNA catabolic process, endonucleolytic
GO:0006281 DNA repair
GO:0006289 nucleotide-excision repair
GO:0033683 nucleotide-excision repair, DNA incision
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Fanconi anemia pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.584863 Hs.627114
RefSeq NM_001146094 NM_001146095 NM_001146096 NM_014967 XM_005254232 XM_005254233 XM_005254234 XM_005254235 XM_006725537 XM_006725538 XM_006725539 XM_006725540
HUGO
OMIM
CCDS CCDS32186 CCDS58344
HPRD 17205
IMGT
EMBL
GenPept
RNA Seq Atlas