Version 5.4
Homo sapiens Gene: LRPPRC
Summary
InnateDB Gene IDBG-49387.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LRPPRC
Gene Name leucine-rich pentatricopeptide repeat containing
Synonyms CLONE-23970; GP130; LRP130; LSFC
Species Homo sapiens
Ensembl Gene ENSG00000138095
Encoded Proteins
IDBP-49389
leucine-rich PPR-motif containing
IDBP-293737
leucine-rich PPR-motif containing
IDBP-293734
leucine-rich PPR-motif containing
IDBP-374286
leucine-rich PPR-motif containing
IDBP-374290
leucine-rich PPR-motif containing
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a leucine-rich protein that has multiple pentatricopeptide repeats (PPR). The precise role of this protein is unknown but studies suggest it may play a role in cytoskeletal organization, vesicular transport, or in transcriptional regulation of both nuclear and mitochondrial genes. The protein localizes primarily to mitochondria and is predicted to have an N-terminal mitochondrial targeting sequence. Mutations in this gene are associated with the French-Canadian type of Leigh syndrome. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:43886508-43996005
Strand Reverse strand
Band p21
Transcripts
ENST00000260665 ENSP00000260665
ENST00000409946 ENSP00000386234
ENST00000409659 ENSP00000386562
ENST00000419884 ENSP00000414207
ENST00000447246 ENSP00000403637
ENST00000463456
ENST00000472420
ENST00000483489
ENST00000467058
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 79 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 79 [view]
Protein-Protein 79 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003697 single-stranded DNA binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0044822 poly(A) RNA binding
GO:0048487 beta-tubulin binding
Biological Process
GO:0000961 negative regulation of mitochondrial RNA catabolic process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0047497 mitochondrion transport along microtubule
GO:0051028 mRNA transport
GO:0070129 regulation of mitochondrial translation
Cellular Component
GO:0000794 condensed nuclear chromosome
GO:0005634 nucleus
GO:0005637 nuclear inner membrane
GO:0005640 nuclear outer membrane
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0016020 membrane
GO:0030529 ribonucleoprotein complex
GO:0042645 mitochondrial nucleoid
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024120
View Gene Order
ENSBTAG00000016368
Not yet available
Pathways
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
REACT_22393
Respiratory electron transport pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_6305
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. pathway
REACT_267716
Orphan transporters pathway
REACT_111083
The citric acid (TCA) cycle and respiratory electron transport pathway
REACT_111217
Metabolism pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.368084 Hs.635473 Hs.714050
RefSeq NM_133259 XM_006711915 XM_006711916
HUGO
OMIM
CCDS CCDS33189
HPRD 06343
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca