InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SMARCD3

Summary

InnateDB Gene

IDBG-49450.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SMARCD3

Gene Name

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3

Synonyms

BAF60C; CRACD3; Rsc6p

Species

Homo sapiens

Ensembl Gene

ENSG00000082014

Encoded Proteins

IDBP-49452

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3

IDBP-49454

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3

IDBP-244901

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3

IDBP-481391

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3

IDBP-482112

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3

IDBP-474342

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and has sequence similarity to the yeast Swp73 protein. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:151238764-151277896

Strand

Reverse strand

Band

q36.1

Transcripts

ENST00000356800	ENSP00000349254
ENST00000262188	ENSP00000262188
ENST00000392811	ENSP00000376558
ENST00000496530
ENST00000469154	ENSP00000417908
ENST00000472789
ENST00000470588
ENST00000485592	ENSP00000417145
ENST00000472988
ENST00000485610
ENST00000472103
ENST00000489503
ENST00000477169
ENST00000460431
ENST00000491651	ENSP00000419886

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	32 [view]
Protein-Protein	32 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0016922	ligand-dependent nuclear receptor binding
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity
GO:0035257	nuclear hormone receptor binding

Biological Process

GO:0002052	positive regulation of neuroblast proliferation
GO:0003007	heart morphogenesis
GO:0003139	secondary heart field specification
GO:0003219	cardiac right ventricle formation
GO:0003407	neural retina development
GO:0006337	nucleosome disassembly
GO:0006338	chromatin remodeling
GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0042692	muscle cell differentiation
GO:0043393	regulation of protein binding
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0045893	positive regulation of transcription, DNA-templated

Cellular Component

GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0016514	SWI/SNF complex
GO:0071564	npBAF complex
GO:0071565	nBAF complex