Homo sapiens Gene: PCDHA1
InnateDB Gene IDBG-49455.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PCDHA1
Gene Name protocadherin alpha 1
Species Homo sapiens
Ensembl Gene ENSG00000204970
Encoded Proteins
protocadherin alpha 1
protocadherin alpha 1
protocadherin alpha 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:140786136-141012347
Strand Forward strand
Band q31.3
ENST00000378133 ENSP00000367373
ENST00000394633 ENSP00000378129
ENST00000504120 ENSP00000420840
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
Biological Process
GO:0007155 cell adhesion
GO:0007156 homophilic cell adhesion
GO:0007399 nervous system development
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
No orthologs found for this gene
UniProt Splice Variant
Entrez Gene
RefSeq NM_018900 NM_031410 NM_031411
CCDS CCDS54912 CCDS54913
HPRD 07319
RNA Seq Atlas