Homo sapiens Gene: PCDHA4 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Gene | IDBG-49550.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | PCDHA4 | ||||||||||||||||||
Gene Name | protocadherin alpha 4 | ||||||||||||||||||
Synonyms | |||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Gene | ENSG00000204967 | ||||||||||||||||||
Encoded Proteins |
protocadherin alpha 4
protocadherin alpha 4
protocadherin alpha 4
protocadherin alpha 4
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Protein Structure |
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Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
Entrez Gene | |||||||||||||||||||
Summary |
This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome 5:140806929-141012344 | ||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||
Band | q31.3 | ||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||
No orthologs found for this gene | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | Q9UN74 | ||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 56141 | ||||||||||||||||||
UniGene | |||||||||||||||||||
RefSeq | NM_031852 NM_018910 NM_018907 NM_031500 | ||||||||||||||||||
HUGO | HGNC:8673 | ||||||||||||||||||
OMIM | 606310 606313 | ||||||||||||||||||
CCDS | CCDS54918 CCDS54916 | ||||||||||||||||||
HPRD | 07322 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AC005609 AF152312 AF152482 BC112102 BC113609 | ||||||||||||||||||
GenPept | AAC34322 AAD43706 AAD43743 AAI12103 AAI13610 | ||||||||||||||||||
RNA Seq Atlas | 56141 | ||||||||||||||||||