Homo sapiens Gene: PCDHA4
Summary
InnateDB Gene IDBG-49550.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PCDHA4
Gene Name protocadherin alpha 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000204967
Encoded Proteins
protocadherin alpha 4
protocadherin alpha 4
protocadherin alpha 4
protocadherin alpha 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:140806929-141012344
Strand Forward strand
Band q31.3
Transcripts
ENST00000356878 ENSP00000349344
ENST00000512229 ENSP00000423470
ENST00000530339 ENSP00000435300
ENST00000618834 ENSP00000481220
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
Biological Process
GO:0007155 cell adhesion
GO:0007156 homophilic cell adhesion
GO:0007399 nervous system development
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 56144
UniGene
RefSeq NM_031500 NM_031852 NM_018910 NM_018907
HUGO HGNC:8670
OMIM 606310 606313
CCDS CCDS54918 CCDS54916
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas 56144