Version 5.4
| Homo sapiens Gene: PCDHA5 | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-49588.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | PCDHA5 | ||||||||
| Gene Name | protocadherin alpha 5 | ||||||||
| Synonyms | |||||||||
| Species | Homo sapiens | ||||||||
| Ensembl Gene | ENSG00000204965 | ||||||||
| Encoded Proteins |
protocadherin alpha 5
protocadherin alpha 5
protocadherin alpha 5
protocadherin alpha 5
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| Entrez Gene | |||||||||
| Summary |
This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 5:140821604-141012344 | ||||||||
| Strand | Forward strand | ||||||||
| Band | q31.3 | ||||||||
| Transcripts |
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| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
| No orthologs found for this gene | |||||||||
| Cross-References | |||||||||
| SwissProt | Q9Y5H7 | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 56143 | ||||||||
| UniGene | |||||||||
| RefSeq | NM_018908 NM_031501 NM_018909 NM_031848 NM_031849 | ||||||||
| HUGO | HGNC:8671 | ||||||||
| OMIM | 606311 | ||||||||
| CCDS | CCDS54917 CCDS47281 CCDS47282 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AC005609 AF152313 AF152483 BC033735 | ||||||||
| GenPept | AAC34321 AAD43707 AAD43744 AAH33735 | ||||||||
| RNA Seq Atlas | 56143 | ||||||||