Homo sapiens Gene: PCDHA5
Summary
InnateDB Gene IDBG-49588.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PCDHA5
Gene Name protocadherin alpha 5
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000204965
Encoded Proteins
protocadherin alpha 5
protocadherin alpha 5
protocadherin alpha 5
protocadherin alpha 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:140821604-141012344
Strand Forward strand
Band q31.3
Transcripts
ENST00000378126 ENSP00000367366
ENST00000529619 ENSP00000433416
ENST00000529859 ENSP00000436557
ENST00000614258 ENSP00000484128
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
Biological Process
GO:0007155 cell adhesion
GO:0007156 homophilic cell adhesion
GO:0007399 nervous system development
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
Orthologs
No orthologs found for this gene
Cross-References
SwissProt Q9Y5H7
TrEMBL
UniProt Splice Variant
Entrez Gene 56143
UniGene
RefSeq NM_018908 NM_031501 NM_031848 NM_018909 NM_031849
HUGO HGNC:8671
OMIM 606311
CCDS CCDS54917 CCDS47281 CCDS47282
HPRD
IMGT
EMBL AC005609 AF152313 AF152483 BC033735
GenPept AAC34321 AAD43707 AAD43744 AAH33735
RNA Seq Atlas 56143