Version 5.4
Homo sapiens Gene: GCSAM
Summary
InnateDB Gene IDBG-49736.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GCSAM
Gene Name germinal center-associated, signaling and motility
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000174500
Encoded Proteins
IDBP-49738
germinal center expressed transcript 2
IDBP-483749
germinal center expressed transcript 2
IDBP-474348
germinal center expressed transcript 2
IDBP-476165
germinal center expressed transcript 2
IDBP-480802
germinal center expressed transcript 2
IDBP-475121
germinal center expressed transcript 2
IDBP-476692
germinal center expressed transcript 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein which may function in signal transduction pathways and whose expression is elevated in germinal cell lymphomas. It contains a putative PDZ-interacting domain, an immunoreceptor tyrosine-based activation motif (ITAM), and two putative SH2 binding sites. In B cells, its expression is specifically induced by interleukin-4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:112120841-112133305
Strand Reverse strand
Band q13.2
Transcripts
ENST00000308910 ENSP00000309487
ENST00000484193 ENSP00000419485
ENST00000470085 ENSP00000417322
ENST00000495418 ENSP00000418558
ENST00000460387 ENSP00000420603
ENST00000488580 ENSP00000419913
ENST00000487901 ENSP00000418849
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0045159 myosin II binding
Biological Process
GO:0050855 regulation of B cell receptor signaling pathway
GO:2000402 negative regulation of lymphocyte migration
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Orthologs
No orthologs found for this gene
Cross-References
SwissProt Q8N6F7
TrEMBL C9IY73 C9JY41
UniProt Splice Variant
Entrez Gene 257144
UniGene Hs.49614
RefSeq NM_001190259 NM_001190260 NM_152785 XM_005247271 XM_005247272
HUGO HGNC:20253
OMIM 607792
CCDS CCDS54622 CCDS2964 CCDS54621
HPRD 09695
IMGT
EMBL AC128688 AF521911 AY212246 BC030506 BM456595
GenPept AAH30506 AAO21701 AAO22147
RNA Seq Atlas 257144

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca